ArticleCurrent biology : CB2009
The spindle position checkpoint requires positional feedback from cytoplasmic microtubules.
Article in Current biology : CB, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Microtubule Feedback and LET-99-Dependent Control of Pulling Forces Ensure Robust Spindle Position.Biophysical journal · 2018Article
- Microtubule dynamics regulation reconstituted in budding yeast lysates.Journal of cell science · 2018Article
- Article
- A comprehensive model to predict mitotic division in budding yeasts.Molecular biology of the cell · 2015Article
- Spatial control of microtubule length and lifetime by opposing stabilizing and destabilizing functions of Kinesin-8.Current biology : CB · 2014Article
- The kinesin-8 Kip3 scales anaphase spindle length by suppression of midzone microtubule polymerization.The Journal of cell biology · 2014Article
- Mitotic exit and separation of mother and daughter cells.Genetics · 2012Review
- Astral microtubule asymmetry provides directional cues for spindle positioning in budding yeast.Experimental cell research · 2012Review
- Article
- Phosphorylation of Lte1 by Cdk prevents polarized growth during mitotic arrest in S. cerevisiae.The Journal of cell biology · 2010Article
- Monitoring spindle orientation: Spindle position checkpoint in charge.Cell division · 2010Article
- The spindle position checkpoint is coordinated by the Elm1 kinase.The Journal of cell biology · 2010Article
- Elm1 kinase activates the spindle position checkpoint kinase Kin4.The Journal of cell biology · 2010Article
- Spindle position is coordinated with cell-cycle progression through establishment of mitotic exit-activating and -inhibitory zones.Molecular cell · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The objective of mitosis is to provide a copy of the genome to each progeny of a cell division. This requires the separation of duplicate chromatids by the spindle apparatus and the delivery of one set of chromosomes to each of the daughter cells. In budding yeast, the fidelity of chromosome delivery depends on the spindle position checkpoint, which prolongs mitosis until one end of the anaphase spindle arrives in the bud. Here we tested the hypothesis that the activity of the spindle position checkpoint depends on persistent interactions between cytoplasmic microtubules and the mother-bud neck, the future site of cytokinesis. We used laser ablation to disrupt microtubule interactions with the bud neck, and we found that loss of microtubules from the neck leads to mitotic exit in a majority of checkpoint-activated cells. Our findings suggest that cytoplasmic microtubules are used to monitor the location of the spindle in the dividing cell and, in the event of positioning errors, relay a signal to inhibit mitotic exit until the spindle is appropriately positioned.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.