ArticleSchizophrenia research2010
Effects of clozapine and olanzapine on cortical thickness in childhood-onset schizophrenia.
Article in Schizophrenia research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Cortical thinning in relation to impaired insight into illness in patients with treatment resistant schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Subcortical volume reduction and cortical thinning 3 months after switching to clozapine in treatment resistant schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Impact cérébral structurel et fonctionnel de la Clozapine chez les patients souffrant de schizophrénie : revue systématique des études longitudinales en neuroimagerie.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2021Article
- Reconsidering brain tissue changes as a mechanistic focus for early intervention in psychiatry.Journal of psychiatry & neuroscience : JPN · 2020Article
- Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia.Molecular psychiatry · 2016Article
- Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings.Schizophrenia research · 2016Review
- Progressive Brain Atrophy and Cortical Thinning in Schizophrenia after Commencing Clozapine Treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Combined stimulant and antipsychotic treatment in adolescents with attention-deficit/hyperactivity disorder: a cross-sectional observational structural MRI study.European child & adolescent psychiatry · 2015Observational
- Effects of lithium on cortical thickness and hippocampal subfield volumes in psychotic bipolar disorder.Journal of psychiatric research · 2015Article
- Finding pieces to the puzzle of brain structure in schizophrenia.Biological psychiatry · 2014Article
- A comparison of neuroimaging findings in childhood onset schizophrenia and autism spectrum disorder: a review of the literature.Frontiers in psychiatry · 2013Review
- Treatments in context: transcranial direct current brain stimulation as a potential treatment in pediatric psychosis.Expert review of neurotherapeutics · 2013Review
- Lack of gender influence on cortical and subcortical gray matter development in childhood-onset schizophrenia.Schizophrenia bulletin · 2013Article
- The neural effects of psychotropic medications in children and adolescents.Child and adolescent psychiatric clinics of North America · 2012Review
- The 3rd Schizophrenia International Research Society Conference, 14-18 April 2012, Florence, Italy: summaries of oral sessions.Schizophrenia research · 2012Article
- Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophrenia.Journal of the American Academy of Child and Adolescent Psychiatry · 2011Article
- Childhood onset schizophrenia: support for a progressive neurodevelopmental disorder.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2011Review
- Age of onset of schizophrenia: perspectives from structural neuroimaging studies.Schizophrenia bulletin · 2011Review
- Annual Research Review: New frontiers in developmental neuropharmacology: can long-term therapeutic effects of drugs be optimized through carefully timed early intervention?Journal of child psychology and psychiatry, and allied disciplines · 2011Review
- Hippocampal volume development in healthy siblings of childhood-onset schizophrenia patients.The American journal of psychiatry · 2011Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLittle is known about the effects of antipsychotic medications on gray matter (GM) in schizophrenia. Although clozapine remains the most effective antipsychotic medication in treatment-refractory cases, it is unknown whether it has a differential effect on GM development.
methodsIn an exploratory analysis, we used automated cortical thickness measurements and prospectively scanned childhood-onset schizophrenia (COS) patients who were maintained on one medication. Two atypical antipsychotic medications, clozapine (n=12, 37 scans) and olanzapine (n=12, 33 scans) were compared with respect to effects on cortical development, in contrast to GM trajectories of matched controls.
resultsThere were no significant differences in the trajectories of cortical thickness between the two treatment groups with the exception of a small circumscribed area in the right prefrontal cortex, where the olanzapine group showed thicker cortex. As expected, both groups showed thinner GM compared to matched controls.
conclusionsAlthough these analyses do not rule out effects of antipsychotic medications on GM development in schizophrenia, they show no differential effect between clozapine and olanzapine on GM trajectory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.