Evidence map›Paper›PMID 19913194›Full record

ReviewAlcohol (Fayetteville, N.Y.)2009

Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions.

Yuval Silberman, Michal Bajo, Ann M Chappell, Daniel T Christian, Maureen Cruz, Marvin R Diaz, Thomas Kash, Anna K Lack, Robert O Messing, George R Siggins and 4 more

Open access · greenAbstract readReview
In one paragraph

Review in Alcohol (Fayetteville, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 95 citations in OpenAlex.

  1. Article
  2. Astrocyte Reactivity by Alcohol Dependence in the Central Amygdala.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Cannabidiol mitigates alcohol dependence and withdrawal with neuroprotective effects in the basolateral amygdala and striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
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  19. Review
  20. Ventral Pallidum GABA Neurons Mediate Motivation Underlying Risky Choice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Yuval SilbermanDepartment of Physiology and Pharmacology, Wake Forest University, School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Michal Bajo
Ann M Chappell
Daniel T Christian
Maureen Cruz
Marvin R Diaz
Thomas Kash
Anna K Lack
Robert O Messing
George R Siggins
Danny Winder
Marisa Roberto
Brian A McCool
Jeff L Weiner
Wake Forest University · USScripps Research Institute · USJohn F. Kennedy Center for the Performing Arts · USUniversity of California, San Francisco · USVanderbilt University · US

Funding

Viral Vector CoreP60AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI Remi Martin-Fardon · 2003 to 2026
$46.3M
Electrophysiology of alcohol in extended amygdelaU01AA013498 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2001 to 2026
$12.6M
INIA: Stress, Anxiety of Alcohol AbuseU01AA013641 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GRANT, KATHLEEN A · 2002 to 2015
$8.8M
The Ethanol - Anxiety Interaction: Cellular MechanismsR01AA014445 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCCOOL, BRIAN A · 2004 to 2023
$5.2M
SYSTEMIC NEUROPHARMACOLOGYP50AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE · PI EHLERS, CINDY L · 1985 to 2002
$5.1M
Regulation of Ethanol Effects on Synaptic TransmissionR01AA015566 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2006 to 2019
$4.6M
Regulation of GABAA Receptors by PKC epsilon.R37AA013588 · NIAAA · ERNEST GALLO CLINIC AND RESEARCH CENTER · PI MESSING, ROBERT O. · 2003 to 2011
$3.7M
INIA: Stress, Anxiety and Excessive Alcohol Drinking (Administrative Core)U24AA013641 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KATHLEEN A GRANT · 2016 to 2026
$3.4M
Periadolescent Noradrenergic Regulation in the BNSTR01DA019112 · NIDA · VANDERBILT UNIVERSITY · PI WINDER, DANNY G. · 2004 to 2014
$3.3M
Synaptic Correlates of Vulnerability and Resilience to Alcohol Use DisorderR01AA017531 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jeffrey L. Weiner · 2009 to 2026
$2.1M
Synaptic and peptidergic neuroadaptations associated with alcohol dependenceR01AA016985 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2008 to 2012
$2.1M
Translational Centerfor the Neurobehaviral Study of AlcoholP01AA017056 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WEINER, JEFFREY L. · 2008 to 2012
$2.0M
NIAAA NIH HHS AA013498NIAAA NIH HHS AA013588NIAAA NIH HHS AA 013641NIAAA NIH HHS AA013960NIAAA NIH HHS AA014445NIAAA NIH HHS AA015566NIAAA NIH HHS AA016025NIAAA NIH HHS AA016671NIAAA NIH HHS AA016985NIAAA NIH HHS AA017039NIAAA NIH HHS AA017053NIAAA NIH HHS AA017576NIAAA NIH HHS AA017581NIAAA NIH HHS AA017668NIAAA NIH HHS AA06420NIAAA NIH HHS AA10994NIAAA NIH HHS F31 AA017039NIAAA NIH HHS F31 AA017576NIAAA NIH HHS F32 AA016025NIAAA NIH HHS K99 AA017668NIAAA NIH HHS P01 AA017056NIAAA NIH HHS P50 AA006420NIAAA NIH HHS R00 AA017668NIAAA NIH HHS R01 AA013588NIAAA NIH HHS R01 AA013960NIAAA NIH HHS R01 AA014445NIAAA NIH HHS R01 AA015566NIAAA NIH HHS R01 AA016985NIAAA NIH HHS R01 AA017531NIAAA NIH HHS R13 AA017053NIAAA NIH HHS R37 AA013588NIAAA NIH HHS R56 AA014445NIAAA NIH HHS U01 AA013498NIAAA NIH HHS U01 AA013641NIAAA NIH HHS U01 AA016671NIAAA NIH HHS U24 AA013641NIDA NIH HHS DA 019112NIDA NIH HHS R01 DA019112
6 · The paper itself

Abstract

This article summarizes the proceedings of a symposium that was presented at a conference entitled "Alcoholism and Stress: A Framework for Future Treatment Strategies." The conference was held in Volterra, Italy on May 6-9, 2008 and this symposium was chaired by Jeff L. Weiner. The overall goal of this session was to review recent findings that may shed new light on the neurobiological mechanisms that underlie the complex relationships between stress, anxiety, and alcoholism. Dr. Danny Winder described a novel interaction between D1 receptor activation and the corticotrophin-releasing factor (CRF) system that leads to an increase in glutamatergic synaptic transmission in the bed nucleus of the stria terminalis. Dr. Marisa Roberto presented recent data describing how protein kinase C epsilon, ethanol, and CRF interact to alter GABAergic inhibition in the central nucleus of the amygdala. Dr. Jeff Weiner presented recent advances in our understanding of inhibitory circuitry within the basolateral amygdala (BLA) and how acute ethanol exposure enhances GABAergic inhibition in these pathways. Finally, Dr. Brian McCool discussed recent findings on complementary glutamatergic and GABAergic adaptations to chronic ethanol exposure and withdrawal in the BLA. Collectively, these investigators have identified novel mechanisms through which neurotransmitter and neuropeptide systems interact to modulate synaptic activity in stress and anxiety circuits. Their studies have also begun to describe how acute and chronic ethanol exposure influence excitatory and inhibitory synaptic communication in these pathways. These findings point toward a number of novel neurobiological targets that may prove useful for the development of more effective treatment strategies for alcohol use disorders.

Indexed as

AlcoholismAmygdalaAnimalsAnxietyCorticotropin-Releasing HormoneEthanolgamma-Aminobutyric AcidHumansProtein Kinase C-epsilonReceptors, GABA-BStress, PsychologicalSynaptic TransmissionCorticotropin-Releasing HormoneEthanolgamma-Aminobutyric AcidPRKCE protein, humanProtein Kinase C-epsilonReceptors, GABA-B

Identifiers

PMID19913194
PMCPMC2814297
OpenAlexW2148904500

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.