ArticleGene expression patterns : GEP2010
Identification of differentially expressed genes in early inner ear development.
Article in Gene expression patterns : GEP, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Two parallel neural ectoderm progenitors contribute to the developing brain.Nature neuroscience · 2026Article
- Integrated Single-cell Analysis Uncovers Regulatory Logic of Cranial Ectoderm Development.bioRxiv : the preprint server for biology · 2025Article
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- Transcriptomic analysis of mouse cochleae suffering from gentamicin damage reveals the signalling pathways involved in hair cell regeneration.Scientific reports · 2019Article
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- Screen for Slit/Robo signaling in trunk neural cells reveals new players.Gene expression patterns : GEP · 2018Article
- Expression and function of microRNA-9 in the mid-hindbrain area of embryonic chick.BMC developmental biology · 2018Article
- The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns.Neural plasticity · 2018Article
- Cell interactions, signals and transcriptional hierarchy governing placode progenitor induction.Development (Cambridge, England) · 2017Article
- A gene network regulated by FGF signalling during ear development.Scientific reports · 2017Article
- Fgf3 and Fgf16 expression patterns define spatial and temporal domains in the developing chick inner ear.Brain structure & function · 2017Article
- The epigenetic modifier DNMT3A is necessary for proper otic placode formation.Developmental biology · 2016Article
- Gene expression profiling of the inner ear.Journal of anatomy · 2016Review
- A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors.Scientific reports · 2016Article
- Frizzled10 mediates WNT1 and WNT3A signaling in the dorsal spinal cord of the developing chick embryo.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Experimental approaches for gene regulatory network construction: the chick as a model system.Genesis (New York, N.Y. : 2000) · 2013Review
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- Fibroblast growth factor and bone morphogenetic protein signaling are required for specifying prechondrogenic identity in neural crest-derived mesenchyme and initiating the chondrogenic program.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Transcriptomic analysis of the developing and adult mouse cochlear sensory epithelia.PloS one · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
To understand the etiology of congenital hearing loss, a comprehensive understanding of the molecular genetic mechanisms underlying normal ear development is required. We are identifying genes involved in otogenesis, with the longer term goal of studying their mechanisms of action, leading to inner ear induction and patterning. Using Agilent microarrays, we compared the differential expression of a test domain (which consisted of the pre-otic placodal ectoderm with the adjacent hindbrain ectoderm and the underlying mesendodermal tissues) with a rostral control domain (which included tissue that is competent, but not specified, to express inner ear markers in explant assays). We identified 1261 transcripts differentially expressed between the two domains at a 2-fold or greater change: 463 were upregulated and 798 were downregulated in the test domain. We validated the differential expression of several signaling molecules and transcription factors identified in this array using in situ hybridization. Furthermore, the expression patterns of the validated group of genes from the test domain were explored in detail to determine how the timing of their expression relates to specific events of otic induction and development. In conclusion, we identified a number of novel candidate genes for otic placode induction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.