ArticleJournal of neuroendocrinology2010
The role of oestradiol in sexually dimorphic hypothalamic-pituitary-adrena axis responses to intracerebroventricular ethanol administration in the rat.
Article in Journal of neuroendocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- On the importance of including both sexes in animal studies - insights from home-cage monitoring.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Endocrine regulation of circadian rhythms.Npj biological timing and sleep · 2025Review
- Glucocorticoid signaling mediates stress-induced migraine-like behaviors in a preclinical mouse model.Cephalalgia : an international journal of headache · 2024Article
- Neuroendocrine pathogenesis of perimenopausal depression.Frontiers in psychiatry · 2023Review
- Sex Differences in Acute Neuroendocrine Responses to Stressors in Rodents and Humans.Cold Spring Harbor perspectives in biology · 2022Article
- Involvement of Ghrelin Dynamics in Stress-Induced Eating Disorder: Effects of Sex and Aging.International journal of molecular sciences · 2021Review
- Retrospective Hair Cortisol Concentrations from Pretreatment to Early Recovery in Alcohol Use Disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2021Article
- Roles for androgens in mediating the sex differences of neuroendocrine and behavioral stress responses.Biology of sex differences · 2020Review
- Natural and Drug Rewards Engage Distinct Pathways that Converge on Coordinated Hypothalamic and Reward Circuits.Neuron · 2019Article
- Androgens Drive Sex Biases in Hypothalamic Corticotropin-Releasing Hormone Gene Expression After Adrenalectomy of Mice.Endocrinology · 2019Article
- Sex differences in the hypothalamic-pituitary-adrenal axis' response to stress: an important role for gonadal hormones.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Sex differences in the traumatic stress response: the role of adult gonadal hormones.Biology of sex differences · 2018Article
- Hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes: sex differences in regulation of stress responsivity.Stress (Amsterdam, Netherlands) · 2017Review
- Strain and sex based characterization of behavioral expressions in non-induced compulsive-like mice.Physiology & behavior · 2017Article
- Chronic alcohol exposure differentially affects activation of female locus coeruleus neurons and the subcellular distribution of corticotropin releasing factor receptors.Progress in neuro-psychopharmacology & biological psychiatry · 2015Article
- Oral self-administration of EtOH: sex-dependent modulation by running wheel access in C57BL/6J mice.Alcoholism, clinical and experimental research · 2014Article
- Habituation of hypothalamic-pituitary-adrenocortical axis hormones to repeated homotypic stress and subsequent heterotypic stressor exposure in male and female rats.Stress (Amsterdam, Netherlands) · 2014Article
- Estrogen receptor β and oxytocin interact to modulate anxiety-like behavior and neuroendocrine stress reactivity in adult male and female rats.Physiology & behavior · 2014Article
- Gonadal steroid hormones and the hypothalamo-pituitary-adrenal axis.Frontiers in neuroendocrinology · 2014Review
- Adolescent drinking targets corticotropin-releasing factor peptide-labeled cells in the central amygdala of male and female rats.Neuroscience · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Systemic ethanol (EtOH) administration activates the hypothalamic-pituitary-adrenal (HPA) axis of rats in a sexually dimorphic manner. The present studies tested the role played by the central nervous system (CNS) in this phenomenon. To localise the effects of the drug to the brain, we utilised an experimental paradigm whereby a small, nontoxic amount of the drug was delivered via intracerebroventricular (i.c.v.) injection. EtoH administered i.c.v. rapidly diffuses throughout the cerebrospinal fluid and brain, and does not cause neuronal damage or have any long-term physiological or behavioural effects. Experimental groups included intact males, intact cycling females, and ovariectomised (OVX) animals with or without replacement oestradiol (E(2)). Intracerebroventricular EtOH-induced HPA hormonal activation was determined by measuring plasma adrenocorticotrophin (ACTH) levels. Activation of brain areas that both regulate HPA function and are responsive to gonadal hormones was determined using expression of the transcription factor c-fos (Fos) as a marker of neuronal activity. We observed sex- and oestrous cycle- dependent differences in HPA activation by EtOH as measured by both these parameters. ACTH secretion was highest in females in pro-oestrus or oestrus, just prior to or after the endogenous peak of E(2), as was Fos expression in the paraventricular nucleus of the hypothalamus (PVN) and the locus coreuleus (LC) of the brainstem. In OVX animals, E(2) replacement caused an increase in PVN and LC Fos expression in response to i.c.v. EtOH compared to OVX controls, but a decrease in ACTH secretion. Taken together, these results indicate that at the level of the CNS, EtOH stimulates HPA activity more robustly at times when the effects of E(2) are high, but that E(2) alone is not responsible for this effect. The data further suggest that the LC plays an important role in the circuitry, which appears to be different from that activated following the systemic administration of EtOH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.