ArticleJournal of cellular and molecular medicine2011
Bone marrow-derived cells can acquire cardiac stem cells properties in damaged heart.
Article in Journal of cellular and molecular medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Extracellular Vesicle-Enhanced Stem Cell Therapy in Acute Myocardial Infarction: A Case Report of Cardiac Regeneration from a Bypass Surgery.Stem cell reviews and reports · 2025Article
- Role of c-Kit in Myocardial Regeneration and Aging.Frontiers in endocrinology · 2019Review
- Bone Marrow Is a Reservoir for Cardiac Resident Stem Cells.Scientific reports · 2016Article
- Effects of autologous bone marrow-derived stem cell mobilization on acute tubular necrosis and cell apoptosis in rats.Experimental and therapeutic medicine · 2015Article
- Effect of bone marrow stem cell mobilisation on the expression levels of cellular growth factors in a rat model of acute tubular necrosis.Experimental and therapeutic medicine · 2015Article
- Exosome and its roles in cardiovascular diseases.Heart failure reviews · 2015Review
- Stimulating endogenous cardiac repair.Frontiers in cell and developmental biology · 2015Review
- Slow turning lateral vessel bioreactor improves embryoid body formation and cardiogenic differentiation of mouse embryonic stem cells.Cellular reprogramming · 2013Article
- Contribution of bone marrow-derived hematopoietic stem/progenitor cells to the generation of donor-marker⁺ cardiomyocytes in vivo.PloS one · 2013Article
- Local activation of cardiac stem cells for post-myocardial infarction cardiac repair.Journal of cellular and molecular medicine · 2012Review
- Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta.Journal of cellular and molecular medicine · 2012Article
- Prometheus's heart: what lies beneath.Journal of cellular and molecular medicine · 2012Article
- Ultrastructural evidence of exosome secretion by progenitor cells in adult mouse myocardium and adult human cardiospheres.Journal of biomedicine & biotechnology · 2012Article
- Right ventricular outflow tract repair with a cardiac biologic scaffold.Cells, tissues, organs · 2012Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimental data suggest that cell-based therapies may be useful for cardiac regeneration following ischaemic heart disease. Bone marrow (BM) cells have been reported to contribute to tissue repair after myocardial infarction (MI) by a variety of humoural and cellular mechanisms. However, there is no direct evidence, so far, that BM cells can generate cardiac stem cells (CSCs). To investigate whether BM cells contribute to repopulate the Kit(+) CSCs pool, we transplanted BM cells from transgenic mice, expressing green fluorescent protein under the control of Kit regulatory elements, into wild-type irradiated recipients. Following haematological reconstitution and MI, CSCs were cultured from cardiac explants to generate 'cardiospheres', a microtissue normally originating in vitro from CSCs. These were all green fluorescent (i.e. BM derived) and contained cells capable of initiating differentiation into cells expressing the cardiac marker Nkx2.5. These findings indicate that, at least in conditions of local acute cardiac damage, BM cells can home into the heart and give rise to cells that share properties of resident Kit(+) CSCs.
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Registered trials
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