ReviewCNS neuroscience & therapeutics2010
Dopamine, morphine, and nitric oxide: an evolutionary signaling triad.
Review in CNS neuroscience & therapeutics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- The neurobiology of love and addiction: Central nervous system signaling and energy metabolism.Cognitive, affective & behavioral neuroscience · 2025Review
- Mobility Coupled with Motivation Promotes Survival: The Evolution of Cognition as an Adaptive Strategy.Biology · 2023Review
- Gut, Microbiome, and Brain Regulatory Axis: Relevance to Neurodegenerative and Psychiatric Disorders.Cellular and molecular neurobiology · 2018Review
- Reciprocal Evolution of Opiate Science from Medical and Cultural Perspectives.Medical science monitor : international medical journal of experimental and clinical research · 2017Review
- Neurobiological Aspects of Mindfulness in Pain Autoregulation: Unexpected Results from a Randomized-Controlled Trial and Possible Implications for Meditation Research.Frontiers in human neuroscience · 2016Article
- Morphine stimulates nitric oxide release in human mitochondria.Journal of bioenergetics and biomembranes · 2015Article
- Hypoxia defined as a common culprit/initiation factor in mitochondrial-mediated proinflammatory processes.Medical science monitor : international medical journal of experimental and clinical research · 2015Review
- Acute morphine treatments alleviate tremor in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys.PloS one · 2014Article
- Epidemiologic and molecular pathophysiology of chronic opioid dependence and the place of naltrexone extended-release formulations in its clinical management.Substance abuse : research and treatment · 2012Article
- The neurobiological link between compassion and love.Medical science monitor : international medical journal of experimental and clinical research · 2011Article
- Interactive effects of endogenous morphine, nitric oxide, and ethanol on mitochondrial processes.Archives of medical science : AMS · 2010Article
- Biological indications of a novel "short" µ opiate receptor in domestic chicken.Archives of medical science : AMS · 2010Article
- Opioid peptides and opiate alkaloids in immunoregulatory processes.Archives of medical science : AMS · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphine biosynthesis in relatively simple and complex integrated animal systems has been demonstrated. Key enzymes in the biosynthetic pathway have also been identified, that is, CYP2D6 and COMT. Endogenous morphine appears to exert highly selective actions via novel mu opiate receptor subtypes, that is, mu3,-4, which are coupled to constitutive nitric oxide release, exerting general yet specific down regulatory actions in various animal tissues. The pivotal role of dopamine as a chemical intermediate in the morphine biosynthetic pathway in plants establishes a functional basis for its expansion into an essential role as the progenitor catecholamine signaling molecule underlying neural and neuroendocrine transmission across diverse animal phyla. In invertebrate neural systems, dopamine serves as the preeminent catecholamine signaling molecule, with the emergence and limited utilization of norepinephrine in newly defined adaptational chemical circuits required by a rapidly expanding set of physiological demands, that is, motor and motivational networks. In vertebrates epinephrine, emerges as the major end of the catecholamine synthetic pathway consistent with a newly incorporated regulatory modification. Given the striking similarities between the enzymatic steps in the morphine biosynthetic pathway and those driving the evolutionary adaptation of catecholamine chemical species to accommodate an expansion of interactive but distinct signaling systems, it is our overall contention that the evolutionary emergence of catecholamine systems required conservation and selective "retrofit" of specific enzyme activities, that is, COMT, drawn from cellular morphine expression. Our compelling hypothesis promises to initiate the reexamination of clinical studies, adding new information and treatment modalities in biomedicine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.