ArticleClinical and experimental immunology2010
Anti-transglutaminase antibodies in non-coeliac children suffering from infectious diseases.
Article in Clinical and experimental immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Viruses and celiac disease: what do we know ?Clinical and experimental medicine · 2023Pooled it
- Clinical settings in which human leukocyte antigen typing is still useful in the diagnosis of celiac disease.World journal of gastroenterology · 2025Review
- Falsely elevated anti-tissue transglutaminase antibodies in patients with immunoproliferative small intestinal diseases: A case series.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Article
- The risk for celiac disease after Covid-19 infection.BMC gastroenterology · 2023Article
- Effect of helicobacter pylori infection eradication on serum level of anti-tissue transglutaminase in children with celiac disease.BMC pediatrics · 2023Article
- Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Pediatric Coeliac Disease Patients Suggests Potential Pre-Seroconversion Markers.Frontiers in immunology · 2022Article
- Repeat Biopsy to Assess Duodenal Healing in Children With Celiac Disease and Eosinophilic Gastrointestinal Disorders.JPGN reports · 2021Article
- Molecular Biomarkers for Celiac Disease: Past, Present and Future.International journal of molecular sciences · 2020Review
- Efficacy Study of Anti-Endomysium Antibodies for Celiac Disease Diagnosis: A Retrospective Study in a Spanish Pediatric Population.Journal of clinical medicine · 2019Article
- Anti-type 2 transglutaminase antibodies as modulators of type 2 transglutaminase functions: a possible pathological role in celiac disease.Cellular and molecular life sciences : CMLS · 2018Review
- Observational
- Lack of evidence of rotavirus-dependent molecular mimicry as a trigger of coeliac disease.Clinical and experimental immunology · 2016Article
- Evaluation of the ESPGHAN Celiac Guidelines in a North American Pediatric Population.The American journal of gastroenterology · 2015Article
- Screening for celiac disease in the general population and in high-risk groups.United European gastroenterology journal · 2015Review
- Children with celiac disease are more likely to have attended hospital for prior respiratory syncytial virus infection.Digestive diseases and sciences · 2014Article
- Celiac disease in adult patients: specific autoantibodies in the diagnosis, monitoring, and screening.Autoimmune diseases · 2014Article
- Celiac disease in children and adolescents: special considerations.Seminars in immunopathology · 2012Review
- Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anti-transglutaminase antibodies are the diagnostic markers of coeliac disease. A role is suggested for infectious agents in the production of anti-transglutaminase antibodies. The aim was to measure positive anti-transglutaminase antibody levels in children with infectious diseases and to compare immunological and biological characteristics of the anti-transglutaminase antibodies derived from these children with that from coeliac patients. Two hundred and twenty-two children suffering from infectious diseases were enrolled prospectively along with seven biopsy-proven coeliacs. Serum samples were tested for anti-transglutaminase antibodies and anti-endomysium antibodies; positive samples were tested for coeliac-related human leucocyte antigen (HLA)-DQ2/8 and anti-viral antibodies. Purified anti-transglutaminase antibodies from the two study groups were tested for urea-dependent avidity, and their ability to induce cytoskeletal rearrangement and to modulate cell-cycle in Caco-2 cells, using phalloidin staining and bromodeoxyuridine incorporation assays, respectively. Nine of 222 children (4%) tested positive to anti-transglutaminase, one of whom also tested positive for anti-endomysium antibodies. This patient was positive for HLA-DQ2 and was diagnosed as coeliac following intestinal biopsy. Of the eight remaining children, two were positive for HLA-DQ8. Levels of anti-transglutaminase returned to normal in all subjects, despite a gluten-containing diet. Purified anti-transglutaminase of the two study groups induced actin rearrangements and cell-cycle progression. During an infectious disease, anti-transglutaminase antibodies can be produced temporarily and independently of gluten. The infection-triggered anti-transglutaminase antibodies have the same biological properties as that of the coeliacs, with the same in-vivo potential for damage.
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