ReviewClinical and experimental immunology2010
Translational mini-review series on Th17 cells: CD4 T helper cells: functional plasticity and differential sensitivity to regulatory T cell-mediated regulation.
Review in Clinical and experimental immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Silicone breast implant-associated pathologies and T cell-mediated responses.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Article
- Biofilm biology and vaccine strategies for otitis media due to nontypeableJournal of pediatric infectious diseases · 2019Article
- 1,25-Dihydroxyvitamin D3 Does Not Affect MicroRNA Expression When Suppressing Human Th17 Differentiation.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- FOXP3Experimental and therapeutic medicine · 2016Article
- Review
- The role of Th17 and Treg responses in the pathogenesis of RSV infection.Pediatric research · 2015Review
- New insight into the immunomodulatory mechanisms of Tretinoin in NMRI mice.Iranian journal of basic medical sciences · 2014Article
- Of mice and men: how animal models advance our understanding of T-cell function in RA.Nature reviews. Rheumatology · 2014Review
- Predominance of activated, clonally expanded T helper type 17 cells within the CD4+ T cell population in psoriatic lesions.Clinical and experimental immunology · 2013Article
- Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45ro+CD25+CD127(low) regulatory T cells.Arthritis and rheumatism · 2013Article
- Protumor activities of the immune response: insights in the mechanisms of immunological shift, oncotraining, and oncopromotion.Journal of oncology · 2013Article
- Broadening the translational immunology landscape.Clinical and experimental immunology · 2012Article
- Article
- Activated IL-23/IL-17 pathway closely correlates with increased Foxp3 expression in livers of chronic hepatitis B patients.BMC immunology · 2011Article
- Rapid detection, enrichment and propagation of specific T cell subsets based on cytokine secretion.Clinical and experimental immunology · 2011Review
- Pleiotropic effects of transforming growth factor-β in hematopoietic stem-cell transplantation.Transplantation · 2010Review
- Translational mini-review series on Th17 cells: are T helper 17 cells really pathogenic in autoimmunity?Clinical and experimental immunology · 2010Review
- Translational mini-review series on Th17 cells: function and regulation of human T helper 17 cells in health and disease.Clinical and experimental immunology · 2010Review
- Translational mini-review series on Th17 cells: induction of interleukin-17 production by regulatory T cells.Clinical and experimental immunology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
CD4(+) T cells display considerable flexibility in their effector functions, allowing them to tackle most effectively the range of pathogenic infections with which we are challenged. The classical T helper (Th) 1 and Th2 subsets have been joined recently by the Th17 lineage. If not controlled, the potent effector functions (chiefly cytokine production) of which these different cells are capable can lead to (sometimes fatal) autoimmune and allergic inflammation. The primary cell population tasked with providing this control appears to be CD4(+) regulatory T (T(reg)) cells expressing the forkhead box P3 (FoxP3) transcription factor. Here we consider the comparative capacity of FoxP3(+) T(regs) to influence the polarization, expansion and effector function of Th1, Th2 and Th17 cells in vitro and in vivo as well as in relation to human disease. This remains a particularly challenging series of interactions to understand, especially given our evolving understanding of T(reg) and T effector interrelationships, as well as recent insights into functional plasticity that cast doubt upon the wisdom of a strict categorization of T effector cells based on cytokine production.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.