ArticleJournal of cellular biochemistry2010
Nicotine, through upregulating pro-survival signaling, cooperates with NNK to promote transformation.
Article in Journal of cellular biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Nicotine combined with estrogen activates protein kinase PKCι and TAO, while inhibiting specific MAP kinase pathways in cultured human neurons: an atlas of kinase activities for nicotine use disorder.Frontiers in cellular neuroscience · 2026Article
- Nicotine-induced CHRNA5 activation modulates CES1 expression, impacting head and neck squamous cell carcinoma recurrence and metastasis via MEK/ERK pathway.Cell death & disease · 2024Article
- Identification of predictive factors for early relapse in patients with unresectable stage III non-small cell lung cancer receiving consolidation durvalumab after concurrent chemoradiation therapy.Thoracic cancer · 2023Article
- Ambient fine particulate matter inhibits 15-lipoxygenases to promote lung carcinogenesis.Journal of experimental & clinical cancer research : CR · 2019Article
- The Influence of Nicotine on Lung Tumor Growth, Cancer Chemotherapy, and Chemotherapy-Induced Peripheral Neuropathy.The Journal of pharmacology and experimental therapeutics · 2018Review
- SNP rs16969968 as a Strong Predictor of Nicotine Dependence and Lung Cancer Risk in a North Indian PopulationAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Nicotine Inhibits Cisplatin-Induced Apoptosis via Regulating α5-nAChR/AKT Signaling in Human Gastric Cancer Cells.PloS one · 2016Article
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- Connections of nicotine to cancer.Nature reviews. Cancer · 2014Review
- Nicotine increases the resistance of lung cancer cells to cisplatin through enhancing Bcl-2 stability.British journal of cancer · 2014Article
- Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.Molecular cancer research : MCR · 2014Review
- Nicotine and lung cancer.Journal of carcinogenesis · 2013Article
- Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer.Cancer prevention research (Philadelphia, Pa.) · 2011Article
- Guggulsterone targets smokeless tobacco induced PI3K/Akt pathway in head and neck cancer cells.PloS one · 2011Article
- 4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK) promotes lung cancer cell survival by stimulating thromboxane A2 and its receptor.Oncogene · 2011Article
- Sensitization of epithelial growth factor receptors by nicotine exposure to promote breast cancer cell growth.Breast cancer research : BCR · 2011Article
- From smoking to cancers: novel targets to neuronal nicotinic acetylcholine receptors.Journal of oncology · 2011Article
- Nicotinic acetylcholine receptor signaling in tumor growth and metastasis.Journal of oncology · 2011Article
- [Current status of Akt in non-small cell lung cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2010Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Cigarette smoking is a mixture of thousands of compounds, many of which are carcinogens, such as NNK [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone]. Nicotine, as an addictive substance in cigarette, has been shown to promote growth of non-neuronal cells. It is unclear how nicotine cooperates with tobacco-related carcinogens during tumorigenesis. Here, by concurrent treatment of nicotine and NNK, we investigate the effect of the cooperation of these two compounds on cell growth and apoptosis in various different lung epithelial (RLE) or cancer (LKR) cells. We demonstrated that short-term nicotine exposure moderately activated mitogenic signaling pathways (such as PKC, ERK, and Akt) and a mediocre protection against cisplatin-mediated apoptosis. In contrast, NNK strongly stimulated mitogenic signaling and rendered the cells a high resistance to cisplatin. The pre-ligation of nAChR by nicotine interfered with NNK-mediated mitogenic signaling and resistance to cisplatin, the magnitude of which was similar as that exposed to nicotine alone. Interestingly, a week after the exposure to nicotine or nicotine plus NNK, Bcl-2 expression was augmented, accompanied with the increased resistance to cisplatin-induced apoptosis. In comparison, long-term NNK treatment provided very little protection of the cells from cisplatin. We also showed that the combination treatment promoted more cells to grow in an anchorage-independent fashion than NNK exposure alone. Thus, the data suggest that through occupying nAChR, nicotine appears to modulate NNK-mediated signaling and persistently sustain pro-survival activities to promote transformation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.