ReviewClinical reviews in allergy & immunology2011
Prolactin and autoimmunity.
Review in Clinical reviews in allergy & immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Elevated plasma/serum levels of prolactin in patients with systemic sclerosis: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Activity of the neuroendocrine axes in patients with polymyalgia rheumatica before and after TNF-α blocking etanercept treatment.Arthritis research & therapy · 2012Trial
- Prolactin as an immuno-neuroendocrine integrator: linking immune homeostasis, hematopoietic dynamics and iron metabolism.Molecular biology reports · 2026Review
- Immunopathogenesis and Therapeutics of Systemic Lupus Erythematosus: an Integrative Review.Clinical reviews in allergy & immunology · 2025Review
- Prolactin: A Key Immunoregulator in Viral Infections and Autoimmune Diseases.International journal of endocrinology · 2025Review
- Prenatal and childhood air pollution exposure, cellular immune biomarkers, and brain connectivity in early adolescents.Brain, behavior, & immunity - health · 2024Article
- The Effect of Metformin on Plasma Prolactin Levels in Young Women with Autoimmune Thyroiditis.Journal of clinical medicine · 2023Article
- Prolactin and oxytocin: potential targets for migraine treatment.The journal of headache and pain · 2023Review
- The Involvement of Prolactin in Stress-Related Disorders.International journal of environmental research and public health · 2023Review
- ATR-IR Spectroscopy Application to Diagnostic Screening of Advanced Endometriosis.Oxidative medicine and cellular longevity · 2022Article
- Potential for Antigen-Specific Tolerizing Immunotherapy in Systematic Lupus Erythematosus.Frontiers in immunology · 2021Review
- Autoimmune thyroid diseases are more common in patients with prolactinomas: a retrospective case-control study in an Italian cohort.Journal of endocrinological investigation · 2019Article
- Prolactin, autoimmunity, and motherhood: when should women avoid breastfeeding?Clinical rheumatology · 2019Review
- Prolactin and Autoimmunity.Frontiers in immunology · 2018Review
- Prolactin has a pathogenic role in systemic lupus erythematosus.Immunologic research · 2017Article
- The prolactin receptor is expressed in rheumatoid arthritis and psoriatic arthritis synovial tissue and contributes to macrophage activation.Rheumatology (Oxford, England) · 2016Article
- The role of the prolactin/vasoinhibin axis in rheumatoid arthritis: an integrative overview.Cellular and molecular life sciences : CMLS · 2016Review
- Signal transducer and activator of transcription 5 is implicated in disease activity in adult and juvenile onset systemic lupus erythematosus.Clinical rheumatology · 2016Article
- Evaluation of prolactin levels in patients with newly diagnosed pemphigus vulgaris and its correlation with pemphigus disease area index.International journal of women's dermatology · 2016Article
- Prevalence of autoimmune disease in patients with prolactinomas and non-functioning pituitary adenomas.Pituitary · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between prolactin and the immune system has been demonstrated in the last two decades, opening new windows in the field of the immunoendocrinology. Prolactin has an important role in the innate and adaptive immune response. Increased prolactin levels have been described in autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, Sjögren syndrome, and systemic sclerosis among others. Hyperprolactinemia is associated with active disease and organ involvement in systemic lupus erythematosus. Therefore, prolactin is an integral member of the immunoneuroendocrinology network and seems to have a role in pathogenesis of autoimmune diseases. Few controlled studies of dopamine agonist treatment in humans with autoimmune disease have been conducted only in systemic lupus erythematosus patients, which support the potential efficacy of such agents even during pregnancy and postpartum. Further studies are necessary to elucidate the mechanisms by which prolactin affects autoimmune disease activity, increase the inflammatory mechanism, and determine the role of anti-prolactinemic drugs to regulate the immune/inflammatory process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.