ArticleMolecular biology of the cell2010
Centromeric localization of dispersed Pol III genes in fission yeast.
Article in Molecular biology of the cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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Who cites it
90 citing papers in PubMed, 117 citations in OpenAlex.
- TFIIIC regulates SMC complex binding and 3D DNA contacts between tRNA genes.bioRxiv : the preprint server for biology · 2026Article
- The LINC complex component Kms1 and CENP-B protein Cbp1 cooperate to enforce faithful homology-directed DNA repair at the nuclear periphery inGenes & development · 2026Article
- The LINC complex component Kms1 and CENP-B protein Cbp1 cooperate to enforce faithful homology-directed DNA repair at the nuclear periphery inbioRxiv : the preprint server for biology · 2025Article
- Metal ion homeostasis regulates condensin-dependent chromatin architecture and chromosome segregation in Schizosaccharomyces pombe.Journal of microbiology (Seoul, Korea) · 2025Article
- Article
- The chromatin remodeler RSC prevents ectopic CENP-A propagation into pericentromeric heterochromatin at the chromatin boundary.Nucleic acids research · 2022Article
- TheeLife · 2022Article
- SMC complexes: Lifting the lid on loop extrusion.Current opinion in cell biology · 2022Review
- A systematic analysis ofGenome research · 2021Article
- A role for condensin in mediating transcriptional adaptation to environmental stimuli.Life science alliance · 2021Article
- RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes.Life science alliance · 2021Article
- Potential roles of condensin in genome organization and beyond in fission yeast.Journal of microbiology (Seoul, Korea) · 2021Review
- Comparison of loop extrusion and diffusion capture as mitotic chromosome formation pathways in fission yeast.Nucleic acids research · 2021Article
- tRNAs as a Driving Force of Genome Evolution in Yeast.Frontiers in microbiology · 2021Review
- Integrity of a heterochromatic domain ensured by its boundary elements.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan.Aging cell · 2020Article
- Transcription-independent TFIIIC-bound sites cluster near heterochromatin boundaries within lamina-associated domains in C. elegans.Epigenetics & chromatin · 2020Article
- Review
- Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts.Open biology · 2019Article
- Nuclear Mechanics in the Fission Yeast.Cells · 2019Review
30 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The eukaryotic genome is a complex three-dimensional entity residing in the nucleus. We present evidence that Pol III-transcribed genes such as tRNA and 5S rRNA genes can localize to centromeres and contribute to a global genome organization. Furthermore, we find that ectopic insertion of Pol III genes into a non-Pol III gene locus results in the centromeric localization of the locus. We show that the centromeric localization of Pol III genes is mediated by condensin, which interacts with the Pol III transcription machinery, and that transcription levels of the Pol III genes are negatively correlated with the centromeric localization of Pol III genes. This centromeric localization of Pol III genes initially observed in interphase becomes prominent during mitosis, when chromosomes are condensed. Remarkably, defective mitotic chromosome condensation by a condensin mutation, cut3-477, which reduces the centromeric localization of Pol III genes, is suppressed by a mutation in the sfc3 gene encoding the Pol III transcription factor TFIIIC subunit, sfc3-1. The sfc3-1 mutation promotes the centromeric localization of Pol III genes. Our study suggests there are functional links between the process of the centromeric localization of dispersed Pol III genes, their transcription, and the assembly of condensed mitotic chromosomes.
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