ArticleJournal of applied physiology (Bethesda, Md. : 1985)2010
Central and peripheral contributors to skeletal muscle hyperemia: response to passive limb movement.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- Cold pressor-induced sympathetic activation blunts the femoral but not carotid artery vascular responsiveness.Physiological reports · 2025Trial
- Effects of limb posture on reactive hyperemia.European journal of applied physiology · 2011Trial
- Acute sympathetic activation blunts the hyperemic and vasodilatory response to passive leg movement in young healthy males.Physiological reports · 2025Article
- Acute sympathetic activation blunts the hyperemic and vasodilatory response to passive leg movement.Research square · 2024Article
- Concurrent metaboreflex activation increases chronotropic and ventilatory responses to passive leg movement without sex-related differences.European journal of applied physiology · 2023Article
- Locomotor Muscle Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction.Hypertension (Dallas, Tex. : 1979) · 2021Article
- The role of vascular function on exercise capacity in health and disease.The Journal of physiology · 2021Review
- The passive leg movement technique for assessing vascular function: defining the distribution of blood flow and the impact of occluding the lower leg.Experimental physiology · 2019Article
- Physiological Impact and Clinical Relevance of Passive Exercise/Movement.Sports medicine (Auckland, N.Z.) · 2019Review
- Cardiovascular and autonomic responses to passive arm or leg movement in men and women.European journal of applied physiology · 2019Article
- Passive limb movement intervals results in repeated hyperemic responses in those with paraplegia.Spinal cord · 2018Article
- Impact of Nitric Oxide Bioavailability on the Progressive Cerebral and Peripheral Circulatory Impairments During Aging and Alzheimer's Disease.Frontiers in physiology · 2018Article
- Single passive leg movement assessment of vascular function: contribution of nitric oxide.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- CORP: Ultrasound assessment of vascular function with the passive leg movement technique.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
- Acute effect of stretching one leg on regional arterial stiffness in young men.European journal of applied physiology · 2017Article
- Central command increases muscular oxygenation of the non-exercising arm at the early period of voluntary one-armed cranking.Physiological reports · 2017Article
- Single passive leg movement-induced hyperemia: a simple vascular function assessment without a chronotropic response.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Vascular function assessed by passive leg movement and flow-mediated dilation: initial evidence of construct validity.American journal of physiology. Heart and circulatory physiology · 2016Article
- Nitric oxide-mediated vascular function in sepsis using passive leg movement as a novel assessment: a cross-sectional study.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- The cardiovascular response to passive movement is joint dependent.Physiological reports · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The central and peripheral contributions to exercise-induced hyperemia are not well understood. Thus, utilizing a reductionist approach, we determined the sequential peripheral and central responses to passive exercise in nine healthy men (33 +/- 9 yr). Cardiac output, heart rate, stroke volume, mean arterial pressure, and femoral blood flow of the passively moved leg and stationary (control) leg were evaluated second by second during 3 min of passive knee extension with and without a thigh cuff that occluded leg blood flow. Without the thigh cuff, significant transient increases in cardiac output (1.0 +/- 0.6 l/min, Delta15%), heart rate (7 +/- 4 beats/min, Delta12%), stroke volume (7 +/- 5 ml, Delta7%), passive leg blood flow (411 +/- 146 ml/min, Delta151%), and control leg blood flow (125 +/- 68 ml/min, Delta43%) and a transient decrease in mean arterial pressure (3 +/- 3 mmHg, 4%) occurred shortly after the onset of limb movement. Although the rise and fall rates of these variables differed, they all returned to baseline values within 45 s; therefore, continued limb movement beyond 45 s does not maintain an increase in cardiac output or net blood flow. Similar changes in the central variables occurred when blood flow to the passively moving leg was occluded. These data confirm the role of peripheral factors and reveal an essential supportive role of cardiac output in the hyperemia at the onset of passive limb movement. This cardiac output response provides an important potential link between the physiology of active and passive exercise.
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Registered trials
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