ArticleMedical hypotheses2010
Sleep disturbance as a universal risk factor for relapse in addictions to psychoactive substances.
Article in Medical hypotheses, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
108 citing papers in PubMed, 221 citations in OpenAlex.
- Influence of sleep quality on lapse to alcohol use during a quit attempt.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Trial
- Trial
- Correlates of treatment engagement and client outcomes: results of a randomised controlled trial of nabiximols for the treatment of cannabis use disorder.Substance abuse treatment, prevention, and policy · 2022Trial
- Sleep time differs among people who co-use cocaine and cannabis compared to people who only use cocaine.Pharmacology, biochemistry, and behavior · 2021Trial
- Examining sleep over time in a randomized control trial comparing two integrated PTSD and alcohol use disorder treatments.Drug and alcohol dependence · 2020Trial
- Sleep Deprivation Promotes Habitual Control over Goal-Directed Control: Behavioral and Neuroimaging Evidence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Trial
- The Effects of Lithium Carbonate Supplemented with Nitrazepam on Sleep Disturbance during Cannabis Abstinence.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015Trial
- Sleep disturbance and the effects of extended-release zolpidem during cannabis withdrawal.Drug and alcohol dependence · 2011Trial
- Effect of night smoking, sleep disturbance, and their co-occurrence on smoking outcomes.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2011Trial
- Sleep following alcohol intoxication in healthy, young adults: effects of sex and family history of alcoholism.Alcoholism, clinical and experimental research · 2011Trial
- Acute and persistent sex-dependent disruptions of sleep-wake architecture induced by fentanyl self-administration in mice.Neuropharmacology · 2026Article
- Sleep regulates drug seeking and relapse - a perspective.Molecular psychiatry · 2026Review
- Examining circadian rhythm dysregulation using actigraphy among treatment-seeking individuals with alcohol use disorder.Frontiers in neuroscience · 2026Article
- The use ofFrontiers in cell and developmental biology · 2026Review
- Impact of physical activity on sleep in adults recovering from substance use disorders: a protocol for an N-of-1 observational study.BMJ open · 2025Article
- Multimodal Sleep Measurement and Alignment Analysis in Outpatients With Major Depressive Episode: Observational Study.JMIR mHealth and uHealth · 2025Observational
- Effects of methamphetamine-induced sleep disruption on intradimensional/extradimensional attentional set-shifting in adult rhesus monkeys.The Journal of pharmacology and experimental therapeutics · 2025Article
- Sleep and circadian rhythm activity alterations during adolescence in a mouse model of neonatal fentanyl withdrawal syndrome.Neuroscience · 2025Article
- Neurexan Prescription Is Associated with Lower Risk of Sleep Disorder Recurrence and Depression Prevalence as Compared to Z-Drugs and Benzodiazepines: A Retrospective Database Analysis in Germany.Healthcare (Basel, Switzerland) · 2024Article
- The phenotype of recovery XI: associations of sleep quality and perceived stress with discounting and quality of life in substance use recovery.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Relapse to uncontrolled use of a psychoactive substance is arguably the single most defining characteristic of an addiction. Relapse following addiction treatment is very common with serious consequences to individuals, families, and the public system of care, making predictors of relapse a highly significant area of study. Before the turn of the century, most of the addiction treatment outcome literature focused on psychosocial predictors of relapse. More recently, investigating biological predictors of relapse specifically and treatment outcome broadly has gained momentum. This line of research has linked sleep disturbances to the risk of relapse among persons who are recovering from an alcohol addiction. Given common neurobiological and psychosocial processes in sleep and addictive behaviors, we hypothesize that the link between sleep disturbance and relapse risk observed among alcohol addiction generalizes to all other types of psychoactive substances. This hypothesis has the potential for helping develop more effective and targeted treatment approaches for persons with addiction. As initial support for the hypothesis, this paper reviews evidence on common neurobiological processes among various types of psychoactive substances that suggests sleep is a universal risk factor for relapse. A conceptual framework is also presented to articulate causal mechanisms. The paper concludes with implications for research and practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.