ArticleMolecular immunology2010
Reoxygenation of hypoxia-differentiated dentritic cells induces Th1 and Th17 cell differentiation.
Article in Molecular immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Tumor hypoxia: Classification, detection, and its critical role in cancer progression.Biomolecules & biomedicine · 2025Review
- The Application of Drugs and Nano-Therapies Targeting Immune Cells in Hypoxic Inflammation.International journal of nanomedicine · 2024Review
- Quality Verification with a Cluster-Controlled Manufacturing System to Generate Monocyte-Derived Dendritic Cells.Vaccines · 2021Article
- Immuno-Metabolism: The Role of Cancer Niche in Immune Checkpoint Inhibitor Resistance.International journal of molecular sciences · 2021Review
- Role of TLR5 in the Translocation and Dissemination of Commensal Bacteria in the Intestine after Traumatic Hemorrhagic Shock.Journal of immunology research · 2021Article
- Review
- Hypoxia potentiates monocyte-derived dendritic cells for release of tumor necrosis factor α via MAP3K8.Bioscience reports · 2018Article
- Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors.Cell metabolism · 2017Article
- Th17 Polarization under Hypoxia Results in Increased IL-10 Production in a Pathogen-Independent Manner.Frontiers in immunology · 2017Article
- A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment.Frontiers in immunology · 2016Review
- Hand transplants and the mandate for tolerance.Current opinion in organ transplantation · 2014Review
- The Functional Difference of Dendritic Cells in HBeAg Negative Chronic Hepatitis B Patients with Three Different Spleen Deficiency Syndromes and the Therapeutic Evaluation of Chinese Medicine Intervention Based on Syndrome Differentiation.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- HIF-1α influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination.Journal of molecular medicine (Berlin, Germany) · 2013Article
- Tumorigenesis: cell defense against hypoxia?Oncology reviews · 2013Review
- The dendritic cell response to classic, emerging, and homeostatic danger signals. Implications for autoimmunity.Frontiers in immunology · 2013Article
- Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration.European journal of immunology · 2012Article
- Cell biology of ischemia/reperfusion injury.International review of cell and molecular biology · 2012Review
- Optimizing dendritic cell-based immunotherapy: tackling the complexity of different arms of the immune system.Mediators of inflammation · 2012Review
- Hypoxia: a double-edged sword of immunity.Journal of molecular medicine (Berlin, Germany) · 2011Review
- Chronic lung allograft rejection and airway microvasculature: is HIF-1 the missing link?The Journal of clinical investigation · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
Abstract
Dendritic cells (DCs) are often exposed to various oxygen tensions under physiological and pathological conditions. However, the effects of various oxygen tensions on DC functions remain unclear. In this study, we showed that hypoxia-differentiated DCs expressed lower levels of MHC-II molecule, co-stimulatory molecules (CD80, CD86) and proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha), but higher levels of immunoregulatory cytokine transforming growth factor-beta (TGF-beta) than normoxia-differentiated DCs. Unexpectedly, re-exposure of hypoxia-differentiated DCs to saturated oxygen (reoxygenation) completely restored their mature phenotype and function. Specifically, the reoxygenated DCs induced naïve CD4(+) T cells to differentiate into Th1 and Th17 effector cells, but deceased the generation of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs). The data indicate that hypoxic microenvironment suppresses the maturation and function of murine DCs. Reoxygenation of hypoxia-differentiated DCs however results in complete recovery of their mature phenotype and function, and has strong ability to drive immune response toward a proinflammatory direction, suggesting reoxygenated DCs may contribute to inflammation of ischemia-reperfusion injury.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.