ReviewCurrent psychiatry reports2009
Melatonin, circadian rhythms, and the clock genes in bipolar disorder.
Review in Current psychiatry reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Toward a Digital Future in Bipolar Disorder Assessment: A Systematic Review of Disruptions in the Rest-Activity Cycle as Measured by Actigraphy.Frontiers in psychiatry · 2022Pooled it
- Article
- Circadian rhythm, epigenetics and disease interaction.Global medical genetics · 2025Review
- The relationship between sleep and circadian patterns with risk for suicide in bipolar disorder varies by subtype.Journal of psychiatric research · 2025Article
- Sleep and circadian disruption in bipolar disorders: From psychopathology to digital phenotyping in clinical practice.Psychiatry and clinical neurosciences · 2024Review
- Putative Risk Biomarkers of Bipolar Disorder in At-risk Youth.Neuroscience bulletin · 2024Review
- Tryptophan Metabolism in Central Nervous System Diseases: Pathophysiology and Potential Therapeutic Strategies.Aging and disease · 2023Review
- Modafinil's effects on cognition and sleep quality in affectively-stable patients with bipolar disorder: a pilot study.Frontiers in psychiatry · 2023Article
- Is Poor Lithium Response in Individuals with Bipolar Disorder Associated with Increased Degradation of Tryptophan along the Kynurenine Pathway? Results of an Exploratory Study.Journal of clinical medicine · 2022Article
- Evaluating endophenotypes for bipolar disorder.International journal of bipolar disorders · 2021Review
- Crystal structure ofJournal of advanced research · 2020Article
- Role of biological rhythm dysfunction in the development and management of bipolar disorders: a review.General psychiatry · 2020Review
- Investigating the relationship between melatonin levels, melatonin system, microbiota composition and bipolar disorder psychopathology across the different phases of the disease.International journal of bipolar disorders · 2019Article
- Genetic Factors Affecting Seasonality, Mood, and the Circadian Clock.Frontiers in endocrinology · 2018Review
- Circadian Rhythm Dysregulation in Bipolar Spectrum Disorders.Current psychiatry reports · 2017Review
- Gsk3 Signalling and Redox Status in Bipolar Disorder: Evidence from Lithium Efficacy.Oxidative medicine and cellular longevity · 2016Review
- The relationship between sleep quality and neurocognition in bipolar disorder.Journal of affective disorders · 2015Article
- The longitudinal course of sleep timing and circadian preferences in adults with bipolar disorder.Bipolar disorders · 2015Article
- CRY1 Variations Impacts on the Depressive Relapse Rate in a Sample of Bipolar Patients.Psychiatry investigation · 2015Article
- The development and course of bipolar spectrum disorders: an integrated reward and circadian rhythm dysregulation model.Annual review of clinical psychology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep disturbances and dysregulation of circadian rhythms are core elements of bipolar disorder that might be involved in its pathogenesis. It has been proposed that patients with bipolar disorder have an abnormally shifted or arrhythmic circadian system and that the disturbance of circadian rhythms may be caused by an alteration in the circadian clock machinery. Chronotherapeutic strategies based on controlled exposures to environmental stimuli that act on biological rhythms have shown good efficacy in the treatment of illness episodes, thus confirming ex juvantibus the clinical relevance of internal timing in this illness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.