ArticleMolecular pain2009
Antinociceptive action of oxytocin involves inhibition of potassium channel currents in lamina II neurons of the rat spinal cord.
Article in Molecular pain, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- Oxytocin Modulation of Spinal Circuits Drives Therapeutic Benefits of Massage.bioRxiv : the preprint server for biology · 2026Article
- Satellite Glial Cells Control Sensory Neuron Excitability via the Release of Fibulin-2.bioRxiv : the preprint server for biology · 2026Article
- Opposite regulation of medullary pain-related projection neuron excitability in acute and chronic pain.Science advances · 2025Article
- Oxytocin Modifies the Excitability and the Action Potential Shape of the Hippocampal CA1 GABAergic Interneurons.International journal of molecular sciences · 2024Article
- Peripheral Branch Injury Induces Oxytocin Receptor Expression at the Central Axon Terminals of Primary Sensory Neurons.International journal of molecular sciences · 2023Article
- The Comprehensive Neural Mechanism of Oxytocin in Analgesia.Current neuropharmacology · 2022Review
- Article
- Exaggerated potassium current reduction by oxytocin in visceral sensory neurons following chronic intermittent hypoxia.Autonomic neuroscience : basic & clinical · 2020Article
- Propriospinal Neurons of L3-L4 Segments Involved in Control of the Rat External Urethral Sphincter.Neuroscience · 2020Article
- Cellular Mechanisms for Antinociception Produced by Oxytocin and Orexins in the Rat Spinal Lamina II-Comparison with Those of Other Endogenous Pain Modulators.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Pain, Parental Involvement, and Oxytocin in the Neonatal Intensive Care Unit.Frontiers in psychology · 2019Review
- Vasopressin and oxytocin in sensory neurones: expression, exocytotic release and regulation by lactation.Scientific reports · 2018Article
- Oxytocin produces thermal analgesia via vasopressin-1a receptor by modulating TRPV1 and potassium conductance in the dorsal root ganglion neurons.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2018Article
- Article
- Oxytocin - a multifunctional analgesic for chronic deep tissue pain.Current pharmaceutical design · 2015Review
- Effect of sodium ferulate on delayed rectifier KExperimental and therapeutic medicine · 2014Article
- Oxytocin inhibits the activity of acid-sensing ion channels through the vasopressin, V1A receptor in primary sensory neurons.British journal of pharmacology · 2014Article
- Preclinical toxicity screening of intrathecal oxytocin in rats and dogs.Anesthesiology · 2014Article
- Oxytocin activates calcium signaling in rat sensory neurons through a protein kinase C-dependent mechanism.Journal of physiology and biochemistry · 2014Article
- Analgesic strategies aimed at stimulating the endogenous production of allopregnanolone.Frontiers in cellular neuroscience · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGrowing evidence in the literature shows that oxytocin (OT) has a strong spinal anti-nociceptive action. Oxytocinergic axons originating from a subpopulation of paraventricular hypothalamic neurons establish synaptic contacts with lamina II interneurons but little is known about the functional role of OT with respect to neuronal firing and excitability.
resultsUsing the patch-clamp technique, we have recorded lamina II interneurons in acute transverse lumbar spinal cord slices of rats (15 to 30 days old) and analyzed the OT effects on action potential firing ability. In the current clamp mode, we found that bath application of a selective OT-receptor agonist (TGOT) reduced firing in the majority of lamina II interneurons exhibiting a bursting firing profile, but never in those exhibiting a single spike discharge upon depolarization. Interestingly, OT-induced reduction in spike frequency and increase of firing threshold were often observed, leading to a conversion of the firing profile from repetitive and delayed profiles into phasic ones and sometimes further into single spike profile. The observed effects following OT-receptor activation were completely abolished when the OT-receptor agonist was co-applied with a selective OT-receptor antagonist. In current and voltage clamp modes, we show that these changes in firing are strongly controlled by voltage-gated potassium currents. More precisely, transient IA currents and delayed-rectifier currents were reduced in amplitude and transient IA current was predominantly inactivated after OT bath application.
conclusionThis effect of OT on the firing profile of lamina II neurons is in good agreement with the antinociceptive and analgesic properties of OT described in vivo.
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