Evidence map›Paper›PMID 19909264›Full record

ReviewBiochemical Society transactions2009

Gene expression networks: competing mRNA decay pathways in mammalian cells.

Lynne E Maquat, Chenguang Gong

Open access · greenAbstract readReview
In one paragraph

Review in Biochemical Society transactions, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Pervasive changes of mRNA splicing inProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Elements of the cellular metabolic structure.Frontiers in molecular biosciences · 2015
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lynne E MaquatDepartment of Biochemistry and Biophysics and Center for RNA Biology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA. lynne_maquat@urmc.rochester.edu
Chenguang Gong
University of Rochester · US

Funding

REGULATION OF SELENOPROTEIN RNA METABOLISMR01GM059614 · NIGMS · UNIVERSITY OF ROCHESTER · PI MAQUAT, LYNNE E · 1999 to 2022
$9.1M
Regulation of Normal and Defective Human GenesR37GM074593 · NIGMS · UNIVERSITY OF ROCHESTER · PI MAQUAT, LYNNE E · 2014 to 2023
$4.8M
Regulation of Normal and Defective Human GenesR01GM074593 · NIGMS · UNIVERSITY OF ROCHESTER · PI MAQUAT, LYNNE E · 2006 to 2013
$3.1M
NIGMS NIH HHS GM059614NIGMS NIH HHS GM 074593NIGMS NIH HHS R01 GM059614NIGMS NIH HHS R01 GM074593NIGMS NIH HHS R37 GM074593
6 · The paper itself

Abstract

Nonsense-mediated mRNA decay and Staufen1-mediated mRNA decay are mechanistically related pathways that serve distinct purposes. In the present article, we give an overview of each pathway. We describe how a factor that is common to both pathways results in their competition. We also explain how competition between the two pathways contributes to the differentiation of C2C12 myoblasts to multinucleated myotubes.

Indexed as

Gene Regulatory NetworksRNA StabilityAnimalsCell DifferentiationHumansModels, GeneticRNA-Binding ProteinsSignal TransductionRNA-Binding Proteinsstaufen protein, mammalian

Identifiers

PMID19909264
PMCPMC3711687
OpenAlexW2001055151

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.