ArticlePacific Symposium on Biocomputing. Pacific Symposium on Biocomputing2010
Detecting genome-wide haplotype polymorphism by combined use of Mendelian constraints and local population structure.
Article in Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Epigenetic functions enriched in transcription factors binding to mouse recombination hotspots.Proteome science · 2012Article
- Detecting rare variants.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Efficient identification of identical-by-descent status in pedigrees with many untyped individuals.Bioinformatics (Oxford, England) · 2010Article
- A novel approach for haplotype-based association analysis using family data.BMC bioinformatics · 2010Article
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3 authors.
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Abstract
Data from current gene-disease association studies motivate changes to existing haplotype inference methodologies. Many datasets are now comprised of both pedigree and population data so it is desirable to incorporate both sources of information when inferring haplotypes. The availability of high-density SNP data also makes it possible to determine and use the precise locations of recombination events. Our proposed method reconstructs haplotype structure on a genome-wide level by jointly using the information from the Mendelian law of inheritance and local population structure. The method combines in one framework new techniques of recombination event detection, maximum likelihood optimization of population haplotype diversity and our previous algorithm of zero-recombinant haplotype reconstruction. Experiments on both real and simulated datasets prove the efficiency and accuracy of our approach in reconstructing the haplotype structure. Our method makes it possible to reveal the haplotypic variation on a genome-wide level.
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