Evidence map›Paper›PMID 19908020›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2010

Limiting dilution analysis of murine epidermal stem cells using an in vivo regeneration assay.

Lauren R Strachan, Ruby Ghadially

Open access · greenAbstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lauren R StrachanSan Francisco VA Medical Center, University of California, San Francisco, CA, USA.
Ruby Ghadially
San Francisco VA Medical Center · US

Funding

Characterization of Epidermal Stem CellsR01AR053765 · NIAMS · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI GHADIALLY, RUBY · 2005 to 2009
$1.7M
NIAMS NIH HHS R01 AR053765
6 · The paper itself

Abstract

Epidermal stem cells are of major importance for tissue homeostasis, wound repair, tumor initiation, and gene therapy. Here we describe an in vivo regeneration assay to test for the ability of keratinocyte progenitors to maintain an epidermis over the long-term in vivo. Limiting dilution analysis of epidermal repopulating units in this in vivo regeneration assay at sequential time points allows the frequency of short-term (transit amplifying cell) and long-term (stem cell) repopulating cells to be quantified.

Indexed as

Epidermal CellsAnimalsCell Culture TechniquesCell DifferentiationCell LineageCell ProliferationEpidermisKeratinocytesMiceMice, SCIDRegenerationStem Cells

Identifiers

PMID19908020
PMCPMC2783164
OpenAlexW1748941676

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.