ArticlePloS one2009
Diminished macrophage apoptosis and reactive oxygen species generation after phorbol ester stimulation in Crohn's disease.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Exploring the impact of DEP on pediatric Crohn's disease using machine learning and molecular docking methods.Frontiers in pediatrics · 2026Article
- GPx1 deficiency confers increased susceptibility to ferroptosis in macrophages from individuals with active Crohn's disease.Cell death & disease · 2024Article
- Rab32-related antimicrobial pathway is involved in the progression of dextran sodium sulfate-induced colitis.FEBS open bio · 2018Article
- Free-fatty acid receptor-4 (FFA4) modulates ROS generation and COX-2 expression via the C-terminal β-arrestin phosphosensor in Raw 264.7 macrophages.Biochemical pharmacology · 2017Article
- RNY (YRNA)-derived small RNAs regulate cell death and inflammation in monocytes/macrophages.Cell death & disease · 2017Article
- G Protein-coupled pH-sensing Receptor OGR1 Is a Regulator of Intestinal Inflammation.Inflammatory bowel diseases · 2015Article
- Anti-inflammatory effects of zinc in PMA-treated human gingival fibroblast cells.Medicina oral, patologia oral y cirugia bucal · 2015Article
- Defective apoptosis in intestinal and mesenteric adipose tissue of Crohn's disease patients.PloS one · 2014Article
- The role of macrophages and dendritic cells in the initiation of inflammation in IBD.Inflammatory bowel diseases · 2014Review
- A balanced IL-1β activity is required for host response to Citrobacter rodentium infection.PloS one · 2013Article
- Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition.The international journal of biochemistry & cell biology · 2012Article
- 17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli.Journal of leukocyte biology · 2011Article
- Crohn's disease as an immunodeficiency.Expert review of clinical immunology · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCrohn's Disease (CD) is a chronic relapsing disorder characterized by granulomatous inflammation of the gastrointestinal tract. Although its pathogenesis is complex, we have recently shown that CD patients have a systemic defect in macrophage function, which results in the defective clearance of bacteria from inflammatory sites. METHODOLOGY/PRINCIPAL
findingsHere we have identified a number of additional macrophage defects in CD following diacylglycerol (DAG) homolog phorbol-12-myristate-13-acetate (PMA) activation. We provide evidence for decreased DNA fragmentation, reduced mitochondrial membrane depolarization, impaired reactive oxygen species production, diminished cytochrome c release and increased IL-6 production compared to healthy subjects after PMA exposure. The observed macrophage defects in CD were stimulus-specific, as normal responses were observed following p53 activation and endoplasmic reticulum stress.
conclusionThese findings add to a growing body of evidence highlighting disordered macrophage function in CD and, given their pivotal role in orchestrating inflammatory responses, defective apoptosis could potentially contribute to the pathogenesis of CD.
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Registered trials
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