ArticlePloS one2009
Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
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- Immune age and biological age as determinants of vaccine responsiveness among elderly populations: the Human Immunomics Initiative research program.European journal of epidemiology · 2021Article
- Côte d'Ivoire Dual Burden of Disease (CoDuBu): Study Protocol to Investigate the Co-occurrence of Chronic Infections and Noncommunicable Diseases in Rural Settings of Epidemiological Transition.JMIR research protocols · 2017Article
- Pathogen-Host Defense in the Evolution of Depression: Insights into Epidemiology, Genetics, Bioregional Differences and Female Preponderance.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Article
- Article
- Cardiovascular disease and type 2 diabetes in evolutionary perspective: a critical role for helminths?Evolution, medicine, and public health · 2016Review
- The role of inflammation in depression: from evolutionary imperative to modern treatment target.Nature reviews. Immunology · 2016Review
- Depression as sickness behavior? A test of the host defense hypothesis in a high pathogen population.Brain, behavior, and immunity · 2015Article
- Variants of the IL-10 gene associate with muscle strength in elderly from rural Africa: a candidate gene study.Aging cell · 2014Article
- Scarcity of atrial fibrillation in a traditional African population: a community-based study.BMC cardiovascular disorders · 2014Article
- Better immunity in later life: a position paper.Age (Dordrecht, Netherlands) · 2014Review
- The frequency of an IL-18-associated haplotype in Africans.European journal of human genetics : EJHG · 2013Article
- Socioeconomic status determines sex-dependent survival of human offspring.Evolution, medicine, and public health · 2013Article
- The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D).Molecular psychiatry · 2013Article
- The influence of genetic variation on innate immune activation in an environment with high infectious pressure.Genes and immunity · 2012Article
- Risk of cardiovascular disease in a traditional African population with a high infectious load: a population-based study.PloS one · 2012Article
- Inflammatory gene variants in the Tsimane, an indigenous Bolivian population with a high infectious load.Biodemography and social biology · 2011Article
- Article
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic inflammation is involved in the pathogenesis of chronic age-associated, degenerative diseases. Pro-inflammatory host responses that are deleterious later in life may originate from evolutionary selection for genetic variation mediating resistance to infectious diseases under adverse environmental conditions. METHODOLOGY/PRINCIPAL
findingsIn the Upper-East region of Ghana where infection has remained the leading cause of death, we studied the effect on survival of genetic variations at the IL10 gene locus that have been associated with chronic diseases. Here we show that an IL10 haplotype that associated with a pro-inflammatory innate immune response, characterised by low IL-10 (p = 0.028) and high TNF-alpha levels (p = 1.39 x 10(-3)), was enriched among Ghanaian elders (p = 2.46 x 10(-6)). Furthermore, in an environment where the source of drinking water (wells/rivers vs. boreholes) influences mortality risks (HR 1.28, 95% CI [1.09-1.50]), we observed that carriers of the pro-inflammatory haplotype have a survival advantage when drinking from wells/rivers but a disadvantage when drinking from boreholes (p(interaction) = 0.013). Resequencing the IL10 gene region did not uncover any additional common variants in the pro-inflammatory haplotype to those SNPs that were initially genotyped. CONCLUSIONS/SIGNIFICANCE: Altogether, these data lend strong arguments for the selection of pro-inflammatory host responses to overcome fatal infection and promote survival in adverse environments.
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