Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2010
Neural substrates of alcohol-induced smoking urge in heavy drinking nondaily smokers.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Varenicline, naltrexone, and their combination for heavy-drinking smokers: preliminary neuroimaging findings.The American journal of drug and alcohol abuse · 2015Trial
- Brain regions affected by impaired control modulate responses to alcohol and smoking cues.Journal of studies on alcohol and drugs · 2014Trial
- Alcohol attenuates amygdala-frontal connectivity during processing social signals in heavy social drinkers: a preliminary pharmaco-fMRI study.Psychopharmacology · 2013Trial
- Alternative substance paradigm: effectiveness of beverage blinding and effects on acute alcohol responses.Experimental and clinical psychopharmacology · 2012Trial
- Modulating cue-induced craving in alcohol dependence syndrome: A functional magnetic resonance imaging blood oxygen level-dependent activation study of adjunctive cathodal high-definition transcranial direct current stimulation over the insula.Indian journal of psychiatry · 2026Article
- Public attitudes about the support for the establishment of smoke-free environment.Frontiers in public health · 2025Article
- Disrupted brain state dynamics in opioid and alcohol use disorder: attenuation by nicotine use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- The incentive amplifying effects of nicotine: Roles in alcohol seeking and consumption.Advances in pharmacology (San Diego, Calif.) · 2022Review
- Unmasking neurobiological commonalities between addictive disorders and impulse control disorders in Parkinson's disease.Brain imaging and behavior · 2020Review
- Decreased brain connectivity in smoking contrasts with increased connectivity in drinking.eLife · 2019Article
- Differential fMRI BOLD responses in amygdala in intermittent explosive disorder as a function of past Alcohol Use Disorder.Psychiatry research. Neuroimaging · 2016Article
- Current insights into the mechanisms and development of treatments for heavy drinking cigarette smokers.Current addiction reports · 2016Article
- Effects of varenicline on operant self-administration of alcohol and/or nicotine in a rat model of co-abuse.Behavioural brain research · 2016Article
- Cigarette Cravings, Impulsivity, and the Brain.Frontiers in psychiatry · 2015Review
- Effect of cigarette smoking and alcohol consumption on disease activity and physical functioning in ankylosing spondylitis: a cross-sectional study.International journal of clinical and experimental medicine · 2015Article
- Operant self-administration of alcohol and nicotine in a preclinical model of co-abuse.Psychopharmacology · 2014Article
- The association between cue-reactivity in the precuneus and level of dependence on nicotine and alcohol.Drug and alcohol dependence · 2014Article
- Striatal ups and downs: their roles in vulnerability to addictions in humans.Neuroscience and biobehavioral reviews · 2013Review
- Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications.Nature reviews. Neuroscience · 2011Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A strong link exists between cigarette smoking and alcohol use, which may be explained by the experimental observation that alcohol ingestion promotes cigarette craving and precipitates smoking. At the neuroanatomic level, it is unclear where and how alcohol exerts these effects, although the process likely involves the ventral striatum given its function in motivational salience and appetitive reinforcement. In a double-blinded, placebo-controlled, crossover study, heavy drinking nondaily social smokers (ie, light smokers or 'chippers') were examined using functional magnetic resonance imaging after they ingested an acute dose of alcohol or placebo. We probed reactivity in the ventral striatum and other brain regions during exposure to visual smoking vs nonsmoking control cues. We found that alcohol enhanced self-reported ratings of desire to smoke, and in this context, significantly increased ventral striatum responses to smoking compared with control cues. In exploratory analyses, we observed that alcohol dampened orbitofrontal activity across both cue types, whereas dorsolateral prefrontal and anterior cingulate cortex activation to smoking cues was not affected by alcohol. This study bridges a pharmacological challenge approach to the study of brain reactivity to smoking cues, extends prior cigarette cue imaging studies to nondependent smokers, and elucidates a potential neurobiological mechanism to explain the co-consumption of alcohol and cigarettes in nondependent users.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.