ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2010
Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop task.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Exploring the effects of anodal and cathodal high definition transcranial direct current stimulation targeting the dorsal anterior cingulate cortex.Scientific reports · 2018Trial
- Intra-individual changes in Stroop-related activations linked to cigarette abstinence in adolescent tobacco smokers: Preliminary findings.Drug and alcohol dependence · 2016Trial
- The effects of N-Acetylcysteine on frontostriatal resting-state functional connectivity, withdrawal symptoms and smoking abstinence: A double-blind, placebo-controlled fMRI pilot study.Drug and alcohol dependence · 2015Trial
- Nicotine withdrawal modulates frontal brain function during an affective Stroop task.Psychopharmacology · 2012Trial
- Neural correlates of response inhibition and cigarette smoking in late adolescence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Trial
- Network localization of gray matter alterations in chronic smokers using the normative functional connectome.Frontiers in public health · 2026Article
- Altered Spontaneous Brain Activity in Betel Quid Dependence Chewers: A Resting-State Functional MRI Study With Percent Amplitude of Fluctuation.Frontiers in psychiatry · 2022Article
- Nicotine dependence (trait) and acute nicotinic stimulation (state) modulate attention but not inhibitory control: converging fMRI evidence from Go-Nogo and Flanker tasks.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Reduced Cortical Thickness in the Right Caudal Middle Frontal Is Associated With Symptom Severity in Betel Quid-Dependent Chewers.Frontiers in psychiatry · 2020Article
- Structural and Functional Alterations in Betel-Quid Chewers: A Systematic Review of Neuroimaging Findings.Frontiers in psychiatry · 2019Article
- Brain Function Network and Young Adult Smokers: A Graph Theory Analysis Study.Frontiers in psychiatry · 2019Article
- Prefrontal Cortical Activity During the Stroop Task: New Insights into the Why and the Who of Real-World Risky Sexual Behavior.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018Article
- Nicotine Abstinence Influences the Calculation of Salience in Discrete Insular Circuits.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
- Altered Prefrontal and Inferior Parietal Activity During a Stroop Task in Individuals With Problematic Hypersexual Behavior.Frontiers in psychiatry · 2018Article
- Restructuring Reward Mechanisms in Nicotine Addiction: A Pilot fMRI Study of Mindfulness-Oriented Recovery Enhancement for Cigarette Smokers.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Double dissociation of working memory and attentional processes in smokers and non-smokers with and without nicotine.Psychopharmacology · 2015Article
- Measuring cigarette smoking-induced cortical dopamine release: A [¹¹C]FLB-457 PET study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- All cravings are not created equal.Addiction (Abingdon, England) · 2015Article
- Cigarette exposure, dependence, and craving are related to insula thickness in young adult smokers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Trait impulsivity and impaired prefrontal impulse inhibition function in adolescents with internet gaming addiction revealed by a Go/No-Go fMRI study.Behavioral and brain functions : BBF · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Prior research suggests that abrupt initiation of abstinence from cigarette smoking reduces neural cognitive efficiency. When cognitive efficiency is high, processing speed and accuracy are maximized with minimal allocation of cognitive resources. The study presented here tested the effects of resumption of smoking on cognitive response conflict after overnight abstinence from smoking, hypothesizing that smoking would enhance cognitive efficiency. Twenty paid research volunteers who were chronic cigarette smokers abstained from smoking overnight (>12 h) before undergoing fMRI while performing a color-word Stroop task during two separate test sessions: one that did not include smoking before testing and another one that did. Statistical analyses were performed by modeling the Stroop effect (incongruent >congruent) BOLD response within a collection of a priori regions of interest that have consistently been associated with cognitive control. Behavioral assessment alone did not reveal any significant differences in the Stroop effect between the two sessions. BOLD activations, however, indicated that in the right anterior cingulate cortex (ACC), smokers had significantly less task-related activity following smoking (p<0.02). In contrast, the right middle frontal gyrus exhibited significantly greater activity after smoking as compared to the no-smoking session (p<0.003). Exaggerated neural activity in the ACC during nicotine withdrawal may reflect a compensatory mechanism by which cognitive control networks expend excessive energy to support selective attention processes. Resumption of smoking may enhance cognitive control in smokers, involving a reduction in ACC response conflict activity together with improvement in conflict resolution involving the dorsolateral prefrontal cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.