ReviewCurrent opinion in organ transplantation2010
Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis.
Review in Current opinion in organ transplantation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Advanced therapy to cure diabetes: mission impossible is now possible?Frontiers in cell and developmental biology · 2024Review
- Refunctionalization of Decellularized Organ Scaffold of Pancreas by Recellularization: Whole Organ Regeneration into Functional Pancreas.Tissue engineering and regenerative medicine · 2021Article
- Notch1 Has an Important Role in β-Cell Mass Determination and Development of Diabetes.Diabetes & metabolism journal · 2021Article
- Shaping Pancreatic β-Cell Differentiation and Functioning: The Influence of Mechanotransduction.Cells · 2020Review
- Cluster-assembled zirconia substrates promote long-term differentiation and functioning of human islets of Langerhans.Scientific reports · 2018Article
- Effects of Neuropeptide Substance P on Proliferation and β-Cell Differentiation of Adult Pancreatic Ductal Cells.Frontiers in neuroscience · 2018Article
- Review
- Article
- Compensatory Response by Late Embryonic Tubular Epithelium to the Reduction in Pancreatic Progenitors.PloS one · 2015Article
- Tissue engineering approaches to cell-based type 1 diabetes therapy.Tissue engineering. Part B, Reviews · 2014Review
- The regulation of pre- and post-maturational plasticity of mammalian islet cell mass.Diabetologia · 2014Review
- Human fetal liver stromal cell co-culture enhances the differentiation of pancreatic progenitor cells into islet-like cell clusters.Stem cell reviews and reports · 2014Article
- Article
- Maturation of stem cell-derived beta-cells guided by the expression of urocortin 3.The review of diabetic studies : RDS · 2014Review
- Biliary tree stem cells, precursors to pancreatic committed progenitors: evidence for possible life-long pancreatic organogenesis.Stem cells (Dayton, Ohio) · 2013Article
- Article
- Stimulating β-cell regeneration by combining a GPR119 agonist with a DPP-IV inhibitor.PloS one · 2013Article
- β-cell preservation and regeneration for diabetes treatment: where are we now?Diabetes management (London, England) · 2012Article
- Recurrence of autoimmunity following pancreas transplantation.Current diabetes reports · 2011Review
- R-spondin1 deficiency in mice improves glycaemic control in association with increased beta cell mass.Diabetologia · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewDiabetes results from inadequate functional mass of pancreatic beta-cells and therefore replenishing with new glucose-responsive beta-cells is an important therapeutic option. In addition to replication of pre-existing beta-cells, new beta-cells can be produced from differentiated adult cells using in-vitro or in-vivo approaches. This review will summarize recent advances in in-vivo generation of beta-cells from cells that are not beta-cells (neogenesis) and discuss ways to overcome the limitations of this process. RECENT
findingsMultiple groups have shown that adult pancreatic ducts, acinar and even endocrine cells exhibit cellular plasticity and can differentiate into beta-cells in vivo. Several different approaches, including misexpression of transcription factors and tissue injury, have induced neogenesis of insulin-expressing cells in vivo and ameliorated diabetes. SUMMARY: Recent breakthroughs demonstrating cellular plasticity of adult pancreatic cells to form new beta-cells are a positive first step towards developing in-vivo regeneration-based therapy for diabetes. Currently, neogenesis processes are inefficient and do not generate sufficient amounts of beta-cells required to normalize hyperglycemia. However, an improved understanding of mechanisms regulating neogenesis of beta-cells from adult pancreatic cells and of their maturation into functional glucose-responsive beta-cells can make therapies based on in-vivo regeneration a reality.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.