SynthesisThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
The spinothalamic system targets motor and sensory areas in the cerebral cortex of monkeys.
Synthesis in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
162 citing papers in PubMed, 5 syntheses or guidelines pooled it, 363 citations in OpenAlex.
- Neuroimage Signature in Post-Stroke Pain: A Systematic Review.Current pain and headache reports · 2025Pooled it
- Neuroimaging Studies of Chronic Prostatitis/Chronic Pelvic Pain Syndrome.Pain research & management · 2022Pooled it
- ALE meta-analysis reveals dissociable networks for affective and discriminative aspects of touch.Human brain mapping · 2016Pooled it
- Midcingulate Motor Map and Feedback Detection: Converging Data from Humans and Monkeys.Cerebral cortex (New York, N.Y. : 1991) · 2016Pooled it
- A meta-analysis of brain mechanisms of placebo analgesia: consistent findings and unanswered questions.Handbook of experimental pharmacology · 2014Pooled it
- Peak Alpha Frequency Is Not Significantly Altered by Five Days of Experimental Pain and Repetitive Transcranial Stimulation of the Left Dorsolateral Prefrontal Cortex.The European journal of neuroscience · 2025Trial
- Cannabis analgesia in chronic neuropathic pain is associated with altered brain connectivity.Neurology · 2018Trial
- Behavioral responses to noxious stimuli shape the perception of pain.Scientific reports · 2017Trial
- Cortical activation changes during repeated laser stimulation: a magnetoencephalographic study.PloS one · 2011Trial
- Receptor architecture shapes the regional organization of the macaque cingulate cortex.Brain structure & function · 2026Article
- Machine Learning-Derived Neural Signatures of Itch and Pain That Reliably Distinguish the Two Sensations in Humans: A Proof-Of-Concept Study.European journal of pain (London, England) · 2026Article
- Temporal Interference Stimulation of the Motor Cortex Produces Frequency-Dependent Analgesia.bioRxiv : the preprint server for biology · 2026Article
- Caudal Granular Insular Cortex to Somatosensory Cortex I: A Critical Pathway for the Transition of Acute to Chronic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Modulation of Posterior Insula Selectively Enhances Nociceptive Sensory Gating in Humans.medRxiv : the preprint server for health sciences · 2026Article
- The central regulatory network of cough: a cornerstone of cough management.Journal of thoracic disease · 2025Review
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- Future Applications of Central Neuromodulation and Neurophysiological Testing in Cyclic Vomiting Syndrome.Neurogastroenterology and motility · 2025Review
- The Isle of Craig: Neuroanatomical and Functional Evidence for a Role of the Insular Cortex in Subjective Feelings.Current topics in behavioral neurosciences · 2025Review
102 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Classically, the spinothalamic (ST) system has been viewed as the major pathway for transmitting nociceptive and thermoceptive information to the cerebral cortex. There is a long-standing controversy about the cortical targets of this system. We used anterograde transneuronal transport of the H129 strain of herpes simplex virus type 1 in the Cebus monkey to label the cortical areas that receive ST input. We found that the ST system reaches multiple cortical areas located in the contralateral hemisphere. The major targets are granular insular cortex, secondary somatosensory cortex and several cortical areas in the cingulate sulcus. It is noteworthy that comparable cortical regions in humans consistently display activation when subjects are acutely exposed to painful stimuli. We next combined anterograde transneuronal transport of virus with injections of a conventional tracer into the ventral premotor area (PMv). We used the PMv injection to identify the cingulate motor areas on the medial wall of the hemisphere. This combined approach demonstrated that each of the cingulate motor areas receives ST input. Our meta-analysis of imaging studies indicates that the human equivalents of the three cingulate motor areas also correspond to sites of pain-related activation. The cingulate motor areas in the monkey project directly to the primary motor cortex and to the spinal cord. Thus, the substrate exists for the ST system to have an important influence on the cortical control of movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.