ArticleJournal of neurophysiology2010
Interneuron circuits tune inhibition in retinal bipolar cells.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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Who cites it
55 citing papers in PubMed.
- Shared-Scale Predictive Benchmarking of an Acoustic-Radiation-Force Model for Frequency-Dependent Retinal Ganglion Cell Responses.Bioengineering (Basel, Switzerland) · 2026Article
- Bipolar cell networks underlying steady-state intensity encoding in intrinsically photosensitive retinal ganglion cells.iScience · 2026Article
- The mysterious middlemen making your vision pop: understanding the function of amacrine cells.The Journal of physiology · 2025Review
- Inhibitory inputs to an inhibitory interneuron: Spontaneous postsynaptic currents and GABAThe European journal of neuroscience · 2022Article
- Dendro-somatic synaptic inputs to ganglion cells contradict receptive field and connectivity conventions in the mammalian retina.Current biology : CB · 2022Article
- Night skies through animals' eyes-Quantifying night-time visual scenes and light pollution as viewed by animals.Frontiers in cellular neuroscience · 2022Article
- Dopamine D1 and D4 receptors contribute to light adaptation in ON-sustained retinal ganglion cells.Journal of neurophysiology · 2021Article
- Article
- Electrical Imaging of Light-Induced Signals Across and Within Retinal Layers.Frontiers in neuroscience · 2020Article
- Reductions in Calcium Signaling Limit Inhibition to Diabetic Retinal Rod Bipolar Cells.Investigative ophthalmology & visual science · 2019Article
- Rod-cone crossover connectome of mammalian bipolar cells.The Journal of comparative neurology · 2019Article
- Cannabinoids Modulate Light Signaling in ON-Sustained Retinal Ganglion Cells of the Mouse.Frontiers in neural circuits · 2019Article
- Dopamine D1 receptor activation contributes to light-adapted changes in retinal inhibition to rod bipolar cells.Journal of neurophysiology · 2018Article
- Direct measurement of bipolar cell responses to electrical stimulation in wholemount mouse retina.Journal of neural engineering · 2018Article
- Eliminating Glutamatergic Input onto Horizontal Cells Changes the Dynamic Range and Receptive Field Organization of Mouse Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Dopamine-Dependent Sensitization of Rod Bipolar Cells by GABA Is Conveyed through Wide-Field Amacrine Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Multiplexed computations in retinal ganglion cells of a single type.Nature communications · 2017Article
- Article
- Circuit Mechanisms of a Retinal Ganglion Cell with Stimulus-Dependent Response Latency and Activation Beyond Its Dendrites.Current biology : CB · 2017Article
- Inhibitory masking controls the threshold sensitivity of retinal ganglion cells.The Journal of physiology · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
While connections between inhibitory interneurons are common circuit elements, it has been difficult to define their signal processing roles because of the inability to activate these circuits using natural stimuli. We overcame this limitation by studying connections between inhibitory amacrine cells in the retina. These interneurons form spatially extensive inhibitory networks that shape signaling between bipolar cell relay neurons to ganglion cell output neurons. We investigated how amacrine cell networks modulate these retinal signals by selectively activating the networks with spatially defined light stimuli. The roles of amacrine cell networks were assessed by recording their inhibitory synaptic outputs in bipolar cells that suppress bipolar cell output to ganglion cells. When the amacrine cell network was activated by large light stimuli, the inhibitory connections between amacrine cells unexpectedly depressed bipolar cell inhibition. Bipolar cell inhibition elicited by smaller light stimuli or electrically activated feedback inhibition was not suppressed because these stimuli did not activate the connections between amacrine cells. Thus the activation of amacrine cell circuits with large light stimuli can shape the spatial sensitivity of the retina by limiting the spatial extent of bipolar cell inhibition. Because inner retinal inhibition contributes to ganglion cell surround inhibition, in part, by controlling input from bipolar cells, these connections may refine the spatial properties of the retinal output. This functional role of interneuron connections may be repeated throughout the CNS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.