ArticleDevelopment (Cambridge, England)2009
The C. elegans tailless/Tlx homolog nhr-67 regulates a stage-specific program of linker cell migration in male gonadogenesis.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Five new Caenorhabditis species from Indonesia provide exceptions to Haldane's rule and partial fertility of interspecific hybrids.G3 (Bethesda, Md.) · 2025Article
- Five newbioRxiv : the preprint server for biology · 2025Article
- Loss ofmicroPublication biology · 2022Article
- Extrasynaptic acetylcholine signaling through a muscarinic receptor regulates cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Invading, Leading and Navigating Cells inGenetics · 2018Review
- CONSERVED AND EXAPTED FUNCTIONS OF NUCLEAR RECEPTORS IN ANIMAL DEVELOPMENT.Nuclear receptor research · 2017Article
- Transcriptional control of non-apoptotic developmental cell death in C. elegans.Cell death and differentiation · 2016Article
- Suppression of F1 Male-Specific Lethality in Caenorhabditis Hybrids by cbr-him-8.G3 (Bethesda, Md.) · 2015Article
- Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression.Developmental cell · 2015Article
- Article
- Natural reversal of left-right gut/gonad asymmetry in C. elegans males is independent of embryonic chirality.Genesis (New York, N.Y. : 2000) · 2014Article
- Noncanonical cell death in the nematode Caenorhabditis elegans.Methods in enzymology · 2014Review
- Functional transcriptomics of a migrating cell in Caenorhabditis elegans.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Analysis of C. elegans NR2E nuclear receptors defines three conserved clades and ligand-independent functions.BMC evolutionary biology · 2012Article
- The evolution of novelty in conserved gene families.International journal of evolutionary biology · 2012Article
- Gonad morphogenesis defects drive hybrid male sterility in asymmetric hybrid breakdown of Caenorhabditis nematodes.Evolution & developmentArticle
Corrections and comments
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Cell migration is a common event during organogenesis, yet little is known about how migration is temporally coordinated with organ development. We are investigating stage-specific programs of cell migration using the linker cell (LC), a migratory cell crucial for male gonadogenesis of C. elegans. During the L3 and L4 larval stages of wild-type males, the LC undergoes changes in its position along the migratory route, in transcriptional regulation of the unc-5 netrin receptor and zmp-1 zinc matrix metalloprotease, and in cell morphology. We have identified the tailless homolog nhr-67 as a cell-autonomous, stage-specific regulator of timing in LC migration programs. In nhr-67-deficient animals, each of the L3 and L4 stage changes is either severely delayed or never occurs, yet LC development before the early L3 stage or after the mid-L4 stage occurs with normal timing. We propose that there is a basal migration program utilized throughout LC migration that is modified by stage-specific regulators such as nhr-67.
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