ArticleMolecular human reproduction2010
microRNA 21: response to hormonal therapies and regulatory function in leiomyoma, transformed leiomyoma and leiomyosarcoma cells.
Article in Molecular human reproduction, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Noncoding RNAs: the shot callers in tumor immune escape.Signal transduction and targeted therapy · 2020Review
- Variation in MicroRNA Expression Profile of Uterine Leiomyoma with Endometrial Cavity Distortion and Endometrial Cavity Non-Distortion.International journal of molecular sciences · 2018Article
- MicroRNA 21a-5p overexpression impacts mediators of extracellular matrix formation in uterine leiomyoma.Reproductive biology and endocrinology : RB&E · 2018Article
- From Oxidative Stress Damage to Pathways, Networks, and Autophagy via MicroRNAs.Oxidative medicine and cellular longevity · 2018Article
- Human epididymis protein 4 expression positively correlated with miR-21 and served as a prognostic indicator in ovarian cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- MicroRNAs in the pathobiology of sarcomas.Laboratory investigation; a journal of technical methods and pathology · 2015Review
- MiR-21 is involved in radiation-induced bystander effects.RNA biology · 2014Article
- MicroRNA expression in Epstein-Barr virus-associated post-transplant smooth muscle tumours is related to leiomyomatous phenotype.Clinical sarcoma research · 2013Article
- miRNAs regulate expression and function of extracellular matrix molecules.Matrix biology : journal of the International Society for Matrix Biology · 2013Review
- Loss of the repressor REST in uterine fibroids promotes aberrant G protein-coupled receptor 10 expression and activates mammalian target of rapamycin pathway.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- MiR-21 expression in the tumor cell compartment holds unfavorable prognostic value in gliomas.Journal of neuro-oncology · 2013Article
- Regulation of breast cancer and bone metastasis by microRNAs.Disease markers · 2013Review
- microRNA-21 overexpression contributes to cell proliferation by targeting PTEN in endometrioid endometrial cancer.Oncology letters · 2012Article
- MicroRNA-21 correlates with tumorigenesis in malignant peripheral nerve sheath tumor (MPNST) via programmed cell death protein 4 (PDCD4).Journal of cancer research and clinical oncology · 2012Article
- Role of microRNA-21 and programmed cell death 4 in the pathogenesis of human uterine leiomyomas.Fertility and sterility · 2012Article
- Dysregulation of uterine signaling pathways in progesterone receptor-Cre knockout of dicer.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Association of MicroRNA-146a with autoimmune diseases.Inflammation · 2012Review
- The role of progesterone signaling in the pathogenesis of uterine leiomyoma.Molecular and cellular endocrinology · 2012Review
- Minireview: The roles of small RNA pathways in reproductive medicine.Molecular endocrinology (Baltimore, Md.) · 2011Review
Corrections and comments
- Retraction · 2012-10-24Ethical Violations by Author · Falsification/Fabrication of Data · Investigation by Company/Institution · Investigation by ORI · Misconduct - Official Investigation(s) and/or Finding(s) · · Nasser Chegini has finding of misconduct: https://ori.hhs.gov/content/case-summary-chegini-nasser
- Retracted
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Aberrant expression of microRNAs (miRNAs), including miR-21, and alteration of their target genes stability have been associated with cellular transformation and tumorigenesis. We investigated the expression, regulation and function of miR-21 in leiomyomas which develop from myometrial cellular transformation. The results indicated that miR-21 is over-expressed in leiomyomas with specific elevation during the secretory phase of the menstrual cycle and in women who received Depo-Provera and oral contraceptives, but reduced due to GnRHa therapy (P < 0.05). Bioinformatic analysis of microarray gene expression profiles previously obtained from the above cohorts, and myometrial smooth muscle cells (MSMC) and leiomyoma smooth muscle cells (LSMC) treated with GnRHa, transforming growth factor (TGF)-beta and TGF-beta receptor type II (TGF-betaRII) antisense oligomer, indicated that a number of miR-21-predicted target genes were co-expressed and differentially regulated in these cohorts. Gain- and loss-of-function of miR-21 in MSMC, LSMC, transformed LSMC and leiomyosarcoma cell line (SKLM-S1) resulted in differential expression of many genes, including some of the miR-21-predicted/validated target genes, PTEN, PDCD4 and E2F1, and TGF-betaRII, in a cell-specific manner. Gain-of miR-21 function in MSMC and LSMC reduced TGF-beta-induced expression of fibromodulin and TGF-beta-induced factor (P < 0.05), and moderately altered the rate of cell growth and caspase-3/7 activity in these cells. We concluded that miR-21 is aberrantly expressed and hormonally regulated in leiomyomas where, through functional interaction with ovarian steroids and the TGF-beta signaling pathway, either directly or indirectly regulates a number of genes whose products are critical in leiomyoma growth and regression as well as their potential cellular transformation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.