ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2010
Metabolic syndrome and weight gain in adulthood.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Celiac Disease as a Model of Intestinal Malnutrition: Mechanisms and Nutritional Management.Nutrients · 2025Review
- Weight Gain, Comorbidities, and Its Associated Factors Among Korean Adults.Journal of Korean medical science · 2023Article
- Body mass index and prevalence of metabolic syndrome among Korean adults before and after the COVID-19 outbreak: a retrospective longitudinal study.Epidemiology and health · 2023Article
- Gut Microbiome: The Interplay of an "Invisible Organ" with Herbal Medicine and Its Derived Compounds in Chronic Metabolic Disorders.International journal of environmental research and public health · 2022Review
- Reduced leukocyte mitochondrial copy number in metabolic syndrome and metabolically healthy obesity.Frontiers in endocrinology · 2022Article
- Weight Gain Predicts Metabolic Syndrome among North Korean Refugees in South Korea.International journal of environmental research and public health · 2021Article
- Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome.Journal of clinical medicine · 2021Article
- Association Between Weight Gain From Young to Middle Adulthood and Metabolic Syndrome Across Different BMI Categories at Young Adulthood.Frontiers in endocrinology · 2021Article
- Life-course BMI and biomarkers in persons aged 60 years or older: a comparison of the USA and Costa Rica.Public health nutrition · 2019Article
- Changes in Adult BMI and Waist Circumference Are Associated with Increased Risk of Advanced Colorectal Neoplasia.Digestive diseases and sciences · 2017Observational
- Rising Obesity Prevalence and Weight Gain Among Adults Starting Antiretroviral Therapy in the United States and Canada.AIDS research and human retroviruses · 2016Article
- Association of adulthood weight gain with circulating adipokine and insulin resistance in the Japanese population.European journal of clinical nutrition · 2015Article
- Prevalence of metabolic syndrome and pre-metabolic syndrome in health professionals: LATINMETS Brazil study.Diabetology & metabolic syndrome · 2015Article
- Cancer prevention and worksite health promotion: time to join forces.Preventing chronic disease · 2014Article
- Do the interactions between glucocorticoids and sex hormones regulate the development of the metabolic syndrome?Frontiers in endocrinology · 2012Article
- Differences in weight gain in hypertensive and diabetic elderly patients primary care study.The journal of nutrition, health & aging · 2012Article
- Weight loss and low-intensity exercise for the treatment of metabolic syndrome in obese postmenopausal women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2011Article
- Association of changes in body mass index during earlier adulthood and later adulthood with circulating obesity biomarker concentrations in middle-aged men and women.Diabetologia · 2011Article
- Article
- Obesity in aging and art.The journals of gerontology. Series A, Biological sciences and medical sciences · 2010Article
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2 authors.
Funding
Abstract
backgroundThe influence of long-term adult weight history on metabolic risk independent of attained body mass index (BMI) is unknown.
methodsUsing nationally representative data on adults aged 50-64 years from the 1999-2006 National Health and Nutrition Examination Surveys, we examined weight change for two periods of adulthood: prime age (age 25-10 years ago) and midlife (the last 10 years). Weight changes in each period were categorized as stable (gain <10 kg) or gain (gain >or=10 kg) to create weight history comparison groups: stable-stable, gain-stable (prime age gain), stable-gain (midlife gain), and gain-gain (continuous gain). Persons who lost weight were excluded. Logistic regression predicted odds of metabolic syndrome and its subcomponents based on weight history, adjusting for current BMI and covariates.
resultsParticipants in the gain-stable group had 89% elevated odds of metabolic syndrome (odds ratio = 1.89, 95% CI: 1.19-3.01) relative to the stable-stable group, even after adjustment for current BMI. All weight gain groups had increased odds of low HDL and high triglycerides relative to participants with continuously stable weights. No significant associations were found between weight history and hypertension or high glucose.
conclusionsWeight history confers information about metabolic risk factors above and beyond attained weight status. In particular, adult weight gain is related to risk of low HDL and high triglycerides. Weight history may contribute to our understanding of why some obese older persons are metabolically healthy but others are not.
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