Evidence map›Paper›PMID 19906677›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2010

RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease.

Fang Fang, Lih-Fen Lue, Shiqiang Yan, Hongwei Xu, John S Luddy, Doris Chen, Douglas G Walker, David M Stern, Shifang Yan, Ann Marie Schmidt and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 1 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 1 synthesis or guideline pooled it, 319 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Article
  5. International journal of molecular sciences · 2026
    Article
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  7. Immune signaling and function in neurodegeneration.The Journal of clinical investigation · 2026
    Review
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  10. Article
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113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Fang FangP&S 17-410, Department Surgery, College of Physicians and Surgeons, Columbia University, 630 West 168th St., New York, NY 10032, USA.
Lih-Fen Lue
Shiqiang Yan
Hongwei Xu
John S Luddy
Doris Chen
Douglas G Walker
David M Stern
Shifang Yan
Ann Marie Schmidt
John X Chen
Shirley ShiDu Yan
Columbia University · USLangston University · USBanner Sun Health Research Institute · USHarbin Medical University · CNMemorial Sloan Kettering Cancer Center · US

Funding

STRUCTURAL AND FUNCTIONAL PROPERTIESP01AG017490 · NIA · UNIVERSITY OF KANSAS LAWRENCE · PI YAN, SHIRLEY SHIDU · 2000 to 2010
$16.9M
NIA NIH HHS P01 AG017490NIA NIH HHS P01AG17490
6 · The paper itself

Abstract

Microglia are critical for amyloid-beta peptide (Abeta)-mediated neuronal perturbation relevant to Alzheimer's disease (AD) pathogenesis. We demonstrate that overexpression of receptor for advanced glycation end products (RAGE) in imbroglio exaggerates neuroinflammation, as evidenced by increased proinflammatory mediator production, Abeta accumulation, impaired learning/memory, and neurotoxicity in an Abeta-rich environment. Transgenic (Tg) mice expressing human mutant APP (mAPP) in neurons and RAGE in microglia displayed enhanced IL-1beta and TNF-alpha production, increased infiltration of microglia and astrocytes, accumulation of Abeta, reduced acetylcholine esterase (AChE) activity, and accelerated deterioration of spatial learning/memory. Notably, introduction of a signal transduction-defective mutant RAGE (DN-RAGE) to microglia attenuates deterioration induced by Abeta. These findings indicate that RAGE signaling in microglia contributes to the pathogenesis of an inflammatory response that ultimately impairs neuronal function and directly affects amyloid accumulation. We conclude that blockade of microglial RAGE may have a beneficial effect on Abeta-mediated neuronal perturbation relevant to AD pathogenesis.-Fang, F., Lue, L.-F., Yan, S., Xu, H., Luddy, J. S., Chen, D., Walker, D. G., Stern, D. M., Yan, S., Schmidt, A. M., Chen, J. X., Yan, S. S. RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease.

Indexed as

MemorySignal TransductionAlzheimer DiseaseAmyloid beta-PeptidesAnimalsAstrocytesDisease Models, AnimalHumansInflammationInterleukin-1betaLearningMiceMice, TransgenicMicrogliaMitogen-Activated Protein KinasesMutationAmyloid beta-PeptidesInterleukin-1betaMitogen-Activated Protein KinasesMok protein, mouseReceptor for Advanced Glycation End ProductsTumor Necrosis Factor-alpha

Identifiers

PMID19906677
PMCPMC3231946
OpenAlexW2054082659

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.