ArticleProceedings. Biological sciences2010
The relationship between mutation frequency and replication strategy in positive-sense single-stranded RNA viruses.
Article in Proceedings. Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Spillover: Mechanisms, Genetic Barriers, and the Role of Reservoirs in Emerging Pathogens.Microorganisms · 2024Review
- Key Aspects of Coronavirus Avian Infectious Bronchitis Virus.Pathogens (Basel, Switzerland) · 2023Review
- RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic.European journal of medicinal chemistry · 2021Review
- Synthesis of Hetaryl-Substituted Asymmetric Porphyrins and Their Affinity to SARS-CoV-2 Helicase.Russian journal of general chemistry · 2021Article
- The evolutionary dynamics of viruses: virion release strategies, time delays and fitness minima.Virus evolution · 2021Article
- Noise-induced bistability in the quasi-neutral coexistence of viral RNAs under different replication modes.Journal of the Royal Society, Interface · 2018Article
- The virome ofVirus evolution · 2018Article
- Mechanisms of viral mutation.Cellular and molecular life sciences : CMLS · 2016Review
- Investigating intra-host and intra-herd sequence diversity of foot-and-mouth disease virus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- The impact of within-herd genetic variation upon inferred transmission trees for foot-and-mouth disease virus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Article
- Article
- Delayed lysis confers resistance to the nucleoside analogue 5-fluorouracil and alleviates mutation accumulation in the single-stranded DNA bacteriophage ϕX174.Journal of virology · 2014Article
- Observing micro-evolutionary processes of viral populations at multiple scales.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Viral mutation rates: modelling the roles of within-host viral dynamics and the trade-off between replication fidelity and speed.Proceedings. Biological sciences · 2013Article
- Article
- Nucleoside analogue mutagenesis of a single-stranded DNA virus: evolution and resistance.Journal of virology · 2012Article
- Dynamics of alternative modes of RNA replication for positive-sense RNA viruses.Journal of the Royal Society, Interface · 2012Article
- The three faces of riboviral spontaneous mutation: spectrum, mode of genome replication, and mutation rate.PLoS genetics · 2012Article
- Dynamics of a plant RNA virus intracellular accumulation: stamping machine vs. geometric replication.Genetics · 2011Article
- Beyond the consensus: dissecting within-host viral population diversity of foot-and-mouth disease virus by using next-generation genome sequencing.Journal of virology · 2011Article
Corrections and comments
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5 authors.
Funding
Abstract
For positive-sense single-stranded RNA virus genomes, there is a trade-off between the mutually exclusive tasks of transcription, translation and encapsidation. The replication strategy that maximizes the intracellular growth rate of the virus requires iterative genome transcription from positive to negative, and back to positive sense. However, RNA viruses experience high mutation rates, and the proportion of genomes with lethal mutations increases with the number of replication cycles. Thus, intracellular mutant frequency will depend on the replication strategy. Introducing apparently realistic mutation rates into a model of viral replication demonstrates that strategies that maximize viral growth rate could result in an average of 26 mutations per genome by the time plausible numbers of positive strands have been generated, and that virus viability could be as low as 0.1 per cent. At high mutation rates or when a high proportion of mutations are deleterious, the optimal strategy shifts towards synthesizing more negative strands per positive strand, and in extremis towards a 'stamping-machine' replication mode where all the encapsidated genomes come from only two transcriptional steps. We conclude that if viral mutation rates are as high as current estimates suggest, either mutation frequency must be considerably higher than generally anticipated and the proportion of viable viruses produced extremely small, or replication strategies cannot be optimized to maximize viral growth rate. Mechanistic models linking mutation frequency to replication mechanisms coupled with data generated through new deep-sequencing technologies could play an important role in improving the estimates of viral mutation rate.
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