ReviewCurrent biology : CB2009
Conformational changes and signaling in cell and matrix physics.
Review in Current biology : CB, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 78 citations in OpenAlex.
- Architecture mechanics mediated osteogenic progression in bone regeneration of artificial scaffolds.Science advances · 2025Article
- Early stage prediction of bone regeneration using FEA and cell differentiation algorithms with 3D-printed PLA and PCL scaffolds: modeling and application to dorsal double-plating in distal radius fractures.3D printing in medicine · 2025Article
- Stress fiber strain recognition by the LIM protein testin is cryptic and mediated by RhoA.Molecular biology of the cell · 2021Article
- Recent Advances in ROS-Responsive Cell Sheet Techniques for Tissue Engineering.International journal of molecular sciences · 2019Review
- Stem Cell Spheroids and Ex Vivo Niche Modeling: Rationalization and Scaling-Up.Journal of cardiovascular translational research · 2017Review
- Influence of Additive Manufactured Scaffold Architecture on the Distribution of Surface Strains and Fluid Flow Shear Stresses and Expected Osteochondral Cell Differentiation.Frontiers in bioengineering and biotechnology · 2017Article
- Mechanotransduction: use the force(s).BMC biology · 2015Article
- Mechanism of regulation of stem cell differentiation by matrix stiffness.Stem cell research & therapy · 2015Review
- Simple insoluble cues specify stem cell differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Documentation and localization of force-mediated filamin A domain perturbations in moving cells.Nature communications · 2014Article
- Soy isoflavones and cellular mechanics.Journal of bioenergetics and biomembranes · 2014Review
- Review
- Growth induction and low-oxygen apoptosis inhibition of human CD34+ progenitors in collagen gels.BioMed research international · 2013Article
- Mechanical perturbation of filamin A immunoglobulin repeats 20-21 reveals potential non-equilibrium mechanochemical partner binding function.Scientific reports · 2013Article
- Atomic force microscopy - looking at mechanosensors on the cell surface.Journal of cell science · 2012Review
- Altered cell mechanics from the inside: dispersed single wall carbon nanotubes integrate with and restructure actin.Journal of functional biomaterials · 2012Article
- Phage-based molecular probes that discriminate force-induced structural states of fibronectin in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- GFP's mechanical intermediate states.PloS one · 2012Article
- Article
- Thin films: Folded in hierarchy.Nature materials · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Physical factors drive evolution and play important roles in motility and attachment as well as in differentiation. As animal cells adhere to survive, they generate force and 'feel' various mechanical features of their surroundings, with mechanosensory mechanisms based in part on force-induced conformational changes. Single-molecule methods for in vitro nano-manipulation, together with new in situ proteomic approaches that exploit mass spectrometry, are helping to identify and characterize the molecules and mechanics of structural transitions within cells and matrices. Given the diversity of cell and molecular responses, networks of biomolecules with conformations and interactions sculpted by force seem more likely than singular mechanosensors. Elaboration of the proteins that unfold and change structure in the extracellular matrix and in cells is needed - particularly with regard to the force-driven kinetics - in order to understand the systems biology of signaling in development, differentiation, and disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.