Evidence map›Paper›PMID 19906219›Full record

ReviewNutrition reviews2009

Role of nutrients in the development of neonatal immune response.

Susanna Cunningham-Rundles, Hong Lin, Deborah Ho-Lin, Ann Dnistrian, Barrie R Cassileth, Jeffrey M Perlman

Open access · bronzeAbstract readReview
In one paragraph

Review in Nutrition reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Article
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  7. Review
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  16. Article
  17. Article
  18. Early protective and risk factors for allergic rhinitis at age 4½ yr.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2011
    Article
  19. Review
  20. A classification of sociomedical health indicators: perspectives for health administrators and health planners.International journal of health services : planning, administration, evaluation · 1976
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Susanna Cunningham-RundlesDivision of Hematology/Oncology, Host Defenses Program, Department of Pediatrics, Weill Medical College of Cornell University, New York, New York, USA. scrundle@mail.med.cornell.edu
Hong Lin
Deborah Ho-Lin
Ann Dnistrian
Barrie R Cassileth
Jeffrey M Perlman
Memorial Sloan Kettering Cancer Center · USCornell University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024996 · NCRR · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2007 to 2011
$49.6M
VENOGLOBULIN-I IN THE TREATMENT OF SEVERE STEROID DEPENDENT ASTHMAM01RR006020 · NCRR · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI GOTTO, ANTONIO M · 1990 to 2003
$11.7M
Regulation by the Immune Response to Vaccines by BotanicalsP50AT002779 · NCCIH · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI LIVINGSTON, PHILIP O. · 2005 to 2009
$7.2M
RETINOIDS AND EPITHELIAL DIFFERENTIATIONP30CA029502 · NCI · STRANG CANCER PREVENTION CENTER · PI RIVLIN, RICHARD S · 2002 to 2006
$4.1M
ZINC AS A BIOLOGICAL RESPONSE MODIFIERP01CA029502 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI ZHANG, ZUO · 1985 to 2000
$360k
NCCIH NIH HHS 1-P50-AT02779NCCIH NIH HHS P50 AT002779NCI NIH HHS CA 29502NCI NIH HHS P01 CA029502NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA029502NCRR NIH HHS M01RR0004NCRR NIH HHS M01 RR 6020NCRR NIH HHS UL1 RR024996PHS HHS R25 105012
6 · The paper itself

Abstract

Nutrients exert unique regulatory effects in the perinatal period that mold the developing immune system. The interactions of micronutrients and microbial and environmental antigens condition the post-birth maturation of the immune system, influencing reactions to allergens, fostering tolerance towards the emerging gastrointestinal flora and ingested antigens, and defining patterns of host defense against potential pathogens. The shared molecular structures that are present on microbes or certain plants, but not expressed by human cells, are recognized by neonatal innate immune receptors. Exposure to these activators in the environment through dietary intake in early life can modify the immune response to allergens and prime the adaptive immune response towards pathogens that express the corresponding molecular structures.

Indexed as

FemaleGastrointestinal TractHumansImmunity, InnateInfant, NewbornInfant Nutritional Physiological PhenomenaMaleMalnutritionMicronutrientsPregnancyPrenatal Nutritional Physiological PhenomenaMicronutrients

Identifiers

PMID19906219
PMCPMC4566995
OpenAlexW2104404720

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.