ArticleBritish journal of pharmacology2009
Vitamin D - a new treatment for airway remodelling in asthma?
Article in British journal of pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- A case study to investigate the effects of Chlorhexidine mouthwash on serum cytokines levels in children with Asthma.BMC research notes · 2024Article
- Epithelial-Mesenchymal Transition Mechanisms in Chronic Airway Diseases: A Common Process to Target?International journal of molecular sciences · 2023Review
- Research advances in airway remodeling in asthma: a narrative review.Annals of translational medicine · 2022Review
- Article
- Emerging concepts in smooth muscle contributions to airway structure and function: implications for health and disease.American journal of physiology. Lung cellular and molecular physiology · 2016Review
- Effect of vitamin D3 on mild to moderate persistent asthmatic patients: A randomized controlled pilot study.Perspectives in clinical research · 2014Article
- Vitamin D treatment improves survival and infant lung structure after intra-amniotic endotoxin exposure in rats: potential role for the prevention of bronchopulmonary dysplasia.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Vitamin D and Its Role as a Protective Factor in Allergy.International scholarly research notices · 2014Review
- Airway smooth muscle in airway reactivity and remodeling: what have we learned?American journal of physiology. Lung cellular and molecular physiology · 2013Review
- Asthma in children and adolescents: a comprehensive approach to diagnosis and management.Clinical reviews in allergy & immunology · 2012Review
- Vitamin D serum levels in allergic rhinitis: any difference from normal population?Asia Pacific allergy · 2012Article
- Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma.American journal of respiratory and critical care medicine · 2011Article
- Vitamin d and susceptibility of chronic lung diseases: role of epigenetics.Frontiers in pharmacology · 2011Article
- Effects of genetic polymorphisms in Vitamin D metabolic pathway on Vitamin D level and asthma control in South Indian patients with bronchial asthma.Lung India : official organ of Indian Chest SocietyArticle
- Effectiveness of vitamin D3 in severe persistent asthmatic patients: A double blind, randomized, clinical study.Journal of pharmacology & pharmacotherapeuticsArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased airway smooth muscle (ASM) mass plays a critical role in chronic asthmatic airway remodelling. ASM cell hypertrophy and hyperplasia are likely to contribute to increased ASM mass and a variety of mitogens induce ASM proliferation in cell culture. Recent recognition of widespread vitamin D deficiency and identification of the vitamin D receptor on many cells has implicated vitamin D as a potential therapeutic target for many disorders including cancer, infection and asthma. In this issue of British Journal of Pharmacology, Damera et al. show that calcitriol, a secosteroidal modulator of vitamin D receptors, inhibited thrombin and platelet-derived growth factor-induced ASM cell proliferation. They also, perhaps surprisingly, show the glucocorticoid dexamethasone to potentiate mitogen-induced ASM proliferation. Their results begin to elucidate the molecular mechanism(s) utilized by calcitriol to inhibit cell proliferation and suggest hyperphosphorylation of retinoblastoma protein and activation of checkpoint kinase 1 (Chk1) as critical to this process. This study identifies inhibition of ASM proliferation as a cellular effect of vitamin D and supports the hypothesis that vitamin D is a potential treatment for airway remodelling in asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.