ArticleMicrocirculation (New York, N.Y. : 1994)2009
A mathematical model of vasoreactivity in rat mesenteric arterioles: I. Myoendothelial communication.
Article in Microcirculation (New York, N.Y. : 1994), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Functional bias of contractile control in mouse resistance arteries.Scientific reports · 2024Article
- The conducted vasomotor response and the principles of electrical communication in resistance arteries.Physiological reviews · 2024Review
- Modeling Reactive Hyperemia to Better Understand and Assess Microvascular Function: A Review of Techniques.Annals of biomedical engineering · 2023Review
- Can endothelial hemoglobin-α regulate nitric oxide vasodilatory signaling?American journal of physiology. Heart and circulatory physiology · 2017Article
- Calcium and electrical signaling in arterial endothelial tubes: New insights into cellular physiology and cardiovascular function.Microcirculation (New York, N.Y. : 1994) · 2017Review
- 3D time-varying simulations of CaInternational journal for numerical methods in biomedical engineering · 2017Article
- Origins of variation in conducted vasomotor responses.Pflugers Archiv : European journal of physiology · 2015Article
- Stochastic model of endothelial TRPV4 calcium sparklets: effect of bursting and cooperativity on EDH.Biophysical journal · 2015Article
- Less is more: minimal expression of myoendothelial gap junctions optimizes cell-cell communication in virtual arterioles.The Journal of physiology · 2014Article
- Role of microprojections in myoendothelial feedback--a theoretical study.The Journal of physiology · 2013Article
- Intercellular communication in the vascular wall: a modeling perspective.Microcirculation (New York, N.Y. : 1994) · 2012Review
- Electrical conduction along endothelial cell tubes from mouse feed arteries: confounding actions of glycyrrhetinic acid derivatives.British journal of pharmacology · 2012Article
- Applicability of cable theory to vascular conducted responses.Biophysical journal · 2012Article
- Sympathetic nerve stimulation induces local endothelial Ca2+ signals to oppose vasoconstriction of mouse mesenteric arteries.American journal of physiology. Heart and circulatory physiology · 2012Article
- BKCa and KV channels limit conducted vasomotor responses in rat mesenteric terminal arterioles.Pflugers Archiv : European journal of physiology · 2012Article
- Multiple factors influence calcium synchronization in arterial vasomotion.Biophysical journal · 2012Article
- The nanostructure of myoendothelial junctions contributes to signal rectification between endothelial and vascular smooth muscle cells.PloS one · 2012Article
- Multiscale FEM modeling of vascular tone: from membrane currents to vessel mechanics.IEEE transactions on bio-medical engineering · 2011Article
- Nitric oxide signaling in the microcirculation.Critical reviews in biomedical engineering · 2011Review
- Modeling Ca2+ signaling in the microcirculation: intercellular communication and vasoreactivity.Critical reviews in biomedical engineering · 2011Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
To study the effect of myoendothelial communication on vascular reactivity, we integrated detailed mathematical models of Ca(2+) dynamics and membrane electrophysiology in arteriolar smooth muscle (SMC) and endothelial (EC) cells. Cells are coupled through the exchange of Ca(2+), Cl(-), K(+), and Na(+) ions, inositol 1,4,5-triphosphate (IP(3)), and the paracrine diffusion of nitric oxide (NO). EC stimulation reduces intracellular Ca(2+) ([Ca(2+)](i)) in the SMC by transmitting a hyperpolarizing current carried primarily by K(+). The NO-independent endothelium-derived hyperpolarization was abolished in a synergistic-like manner by inhibition of EC SK(Ca) and IK(Ca) channels. During NE stimulation, IP(3) diffusing from the SMC induces EC Ca(2+) release, which, in turn, moderates SMC depolarization and [Ca(2+)](i) elevation. On the contrary, SMC [Ca(2+)](i) was not affected by EC-derived IP(3). Myoendothelial Ca(2+) fluxes had no effect in either cell. The EC exerts a stabilizing effect on calcium-induced calcium release-dependent SMC Ca(2+) oscillations by increasing the norepinephrine concentration window for oscillations. We conclude that a model based on independent data for subcellular components can capture major features of the integrated vessel behavior. This study provides a tissue-specific approach for analyzing complex signaling mechanisms in the vasculature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.