Trial reportJournal of periodontology2009
Serum inflammatory mediators in pregnancy: changes after periodontal treatment and association with pregnancy outcomes.
Trial report in Journal of periodontology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 9 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Temporal dynamics of early inflammatory markers after professional dental cleaning: a meta-analysis and spline-based meta-regression of TNF-α, IL-1β, IL-6, and (hs)CRP.Frontiers in immunology · 2025Pooled it
- Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.The Cochrane database of systematic reviews · 2022Pooled it
- Changes in Inflammatory Cytokines in Saliva after Non-Surgical Periodontal Therapy: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Effect of per Capita Income on the Relationship between Periodontal Disease during Pregnancy and the Risk of Preterm Birth and Low Birth Weight Newborn. Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.The Cochrane database of systematic reviews · 2019Pooled it
- Periodontal therapy for the management of cardiovascular disease in patients with chronic periodontitis.The Cochrane database of systematic reviews · 2017Pooled it
- Treating periodontal disease for preventing adverse birth outcomes in pregnant women.The Cochrane database of systematic reviews · 2017Pooled it
- Pooled it
- Periodontal disease as a risk factor for adverse pregnancy outcomes: a systematic review and meta-analysis of case-control studies.Odontology · 2012Pooled it
- Non-Surgical Treatment of Periodontal Disease in a Pregnant Caucasian Women Population: Adverse Pregnancy Outcomes of a Randomized Clinical Trial.International journal of environmental research and public health · 2019Trial
- Effect of non-surgical periodontal therapy on the degree of gingival inflammation and stress markers related to pregnancy.Journal of applied oral science : revista FOB · 2018Trial
- Placental ABCA1 Expression Is Increased in Spontaneous Preterm Deliveries Compared with Iatrogenic Preterm Deliveries and Term Deliveries.BioMed research international · 2017Trial
- Saliva/pathogen biomarker signatures and periodontal disease progression.Journal of dental research · 2011Trial
- Design characteristics of studies evaluating the effect of non-surgical periodontal treatment on systemic health outcomes.Journal of periodontology · 2026Review
- Mathematical Modeling of Obstetric Variables: Influence of COVID-19, Periodontal Disease and Dental Care During Pregnancy.Biomedicines · 2025Article
- The bidirectional relationship between periodontal disease and pregnancyFrontiers in microbiology · 2023Review
- Interaction between stress, cytokines, and salivary cortisol in pregnant and non-pregnant women with gingivitis.Clinical oral investigations · 2021Article
- Systemic inflammatory burden and local inflammation in periodontitis: What is the link between inflammatory biomarkers in serum and gingival crevicular fluid?Clinical and experimental dental research · 2019Article
- Salivary and serum inflammatory mediators among pre-conception women with periodontal disease.BMC oral health · 2016Article
- Relationship between periodontal parameters and plasma cytokine profiles in pregnant woman with preterm birth or low birth weight.Clinical oral investigations · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe purposes of this study were to determine: 1) if periodontal treatment in pregnant women before 21 weeks of gestation alters levels of inflammatory mediators in serum; and 2) if changes in these mediators are associated with birth outcomes.
methodsA total of 823 pregnant women with periodontitis were randomly assigned to receive scaling and root planing before 21 weeks of gestation or after delivery. Serum obtained between 13 and 16 weeks, 6 days (study baseline) and 29 to 32 weeks of gestation was analyzed for C-reactive protein; prostaglandin E(2); matrix metalloproteinase-9; fibrinogen; endotoxin; interleukin (IL)-1 beta, -6, and -8, and tumor necrosis factor-alpha. Cox regression, multiple linear regression, and the t, chi(2), and Fisher exact tests were used to examine associations among the biomarkers, periodontal treatment, and gestational age at delivery and birth weight.
resultsA total of 796 women had baseline serum data, and 620 women had baseline and follow-up serum and birth data. Periodontal treatment did not significantly alter the level of any biomarker (P >0.05). Neither baseline levels nor the change from baseline in any biomarker were significantly associated with preterm birth or infant birth weight (P >0.05). In treatment subjects, the change in endotoxin was negatively associated with the change in probing depth (P <0.05).
conclusionsNon-surgical mechanical periodontal treatment in pregnant women, delivered before 21 weeks of gestation, did not reduce systemic (serum) markers of inflammation. In pregnant women with periodontitis, levels of these markers at 13 to 17 weeks and 29 to 32 weeks of gestation were not associated with infant birth weight or a risk for preterm birth.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.