ArticleCancer chemotherapy and pharmacology2010
Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinoma.
Article in Cancer chemotherapy and pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Characteristics and outcomes of gemcitabine-associated pulmonary hypertension.ERJ open research · 2024Article
- Chemotherapy-Associated Pulmonary Toxicity-Case Series from a Single Center.South Asian journal of cancer · 2021Article
- Intravesically instilled gemcitabine-induced lung injury in a patient with invasive urothelial carcinoma: A case report.World journal of clinical cases · 2020Article
- Overview of imaging findings associated with systemic therapies in advanced epithelial ovarian cancer.Abdominal radiology (New York) · 2020Review
- Colorectal metastasis to the gallbladder mimicking a primary gallbladder malignancy: histopathological and molecular characteristics.Histopathology · 2019Article
- Organizing pneumonia after pancreatic cancer treatment with nab-paclitaxel and gemcitabine: a case report.BJR case reports · 2018Article
- Surface-enhanced Raman scattering investigation of targeted delivery and controlled release of gemcitabine.International journal of nanomedicine · 2017Article
- Successful treatment of gemcitabine-induced acute interstitial pneumonia with imatinib mesylate: a case report.BMC cancer · 2016Article
- Gemcitabine-Related Pneumonitis in Pancreas Adenocarcinoma--An Infrequent Event: Elucidation of Risk Factors and Management Implications.Clinical colorectal cancer · 2016Article
- Pneumomediastinum as a complication of SABR for lung metastases.Radiation oncology (London, England) · 2015Article
- Gemcitabine-Induced Pulmonary Toxicity: A Case Report of Pulmonary Veno-Occlusive Disease.Clinical Medicine Insights. Oncology · 2015Article
- Combined chemotherapy with gemcitabine and carboplatin for metastatic urothelial carcinomas in patients with high renal insufficiency.International journal of clinical oncology · 2013Article
- Severe eosinophilic pneumonia presenting during gemcitabine adjuvant chemotherapy.World journal of surgical oncology · 2013Article
- Interstitial lung disease associated with gemcitabine treatment in patients with non-small-cell lung cancer and pancreatic cancer.Journal of cancer research and clinical oncology · 2011Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gemcitabine is a chemotherapy agent that may cause unpredictable side effects. In this report, we describe a fatal gemcitabine-induced pulmonary toxicity in a patient with gallbladder metastatic adenocarcinoma. A 72-year-old patient was submitted to an elective laparoscopic cholecystectomy, and a tubular adenocarcinoma in the gallbladder was incidentally diagnosed. CT scan and ultrasound before the surgery did not show any tumor. After the surgery a Pet scan was positive for a hot-spot in the left colon. The colonic lesion was conveniently removed and the histology evaluation confirmed the diagnosis of adenocarcinoma tubular. The patient was then submitted to three sections of 1,600 mg/m2 of gemcitabine with intervals of 1 week. Three weeks later he developed severe respiratory distress. A helicoidal CT scan showed diffuse and severe interstitial pneumonitis, and lung biopsy confirmed accelerated usual interstitial pneumonia consistent with drug-induced toxicity. The patient presented unfavorable evolution with progressive worsening of respiratory function, hypotension, and renal failure. He died 1 month later in spite of methylprednisolone pulse therapy, large spectrum antimicrobial therapy, and full support of respiratory, hemodynamic and renal systems. Gemcitabine-induced pulmonary toxicity is usually a dramatic condition. Physicians should suspect pulmonary toxicity in patients with respiratory distress after gemcitabine chemotherapy, mainly in elderly patients.
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