Evidence map›Paper›PMID 19904266›Full record

ArticleBritish journal of cancer2009

Vitamin D receptor polymorphisms and prognosis of patients with epithelial ovarian cancer.

S Tamez, C Norizoe, K Ochiai, D Takahashi, A Shimojima, Y Tsutsumi, N Yanaihara, T Tanaka, A Okamoto, M Urashima

Abstract read
In one paragraph

Article in British journal of cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. The role of bile acids in carcinogenesis.Cellular and molecular life sciences : CMLS · 2022
    Review
  8. Vitamin D Exposure and Ovarian Cancer Risk and Prognosis.International journal of environmental research and public health · 2020
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Prediagnostic 25-hydroxyvitamin D, VDR and CASR polymorphisms, and survival in patients with colorectal cancer in western European ppulations.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012
    Article
  16. Article
  17. Associations between genetic variants in vitamin D metabolism and asthma characteristics in young African Americans: a pilot study.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2011
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

S TamezDivision of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan.
C Norizoe
K Ochiai
D Takahashi
A Shimojima
Y Tsutsumi
N Yanaihara
T Tanaka
A Okamoto
M Urashima

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecently, the vitamin D receptor (VDR) polymorphism FokI was shown to be associated with susceptibility to ovarian cancer. We aimed to examine whether VDR FokI polymorphisms influence the survivals of patients with epithelial ovarian cancer (EOC).

methodsVDR polymorphisms from FokI in 101 patients with EOC were genotyped by sequencing. Overall survival was compared between FokI single nucleotide polymorphism using Kaplan-Meier survival curves with log-rank tests and the Cox proportional hazard model adjusted for ages, stages, histology, and existence of residual tumour.

resultsThe FokI C/C genotypes were associated with better prognosis compared with the C/T and T/T genotypes (log-rank test: P = 0.008; adjusted hazard ratio, 0.18; 95%CI 0.05-0.61; P = 0.006).

conclusionsThese results suggest that the VDR polymorphisms from the FokI genotype may be associated with improved prognosis of patients with EOC.

Indexed as

Polymorphism, Single NucleotideAdultCohort StudiesDeoxyribonucleases, Type II Site-SpecificFemaleGenotypeHumansMiddle AgedNeoplasms, Glandular and EpithelialOvarian NeoplasmsPrognosisProportional Hazards ModelsReceptors, CalcitriolVitamin D25-hydroxyvitamin DDeoxyribonucleases, Type II Site-Specificendodeoxyribonuclease FokIReceptors, CalcitriolVitamin D

Identifiers

PMID19904266
PMCPMC2777264

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.