ArticlePhysiological genomics2010
Parent-of-origin effects on voluntary exercise levels and body composition in mice.
Article in Physiological genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Can a Hybrid Line Break a Selection Limit on Behavioral Evolution in Mice?Behavior genetics · 2025Article
- DNA Methylation Analysis of Imprinted Genes in the Cortex and Hippocampus of Cross-Fostered Mice Selectively Bred for Increased Voluntary Wheel-Running.Behavior genetics · 2022Article
- Prevention of tumorigenesis in mice by exercise is dependent on strain background and timing relative to carcinogen exposure.Scientific reports · 2017Article
- R2d2 Drives Selfish Sweeps in the House Mouse.Molecular biology and evolution · 2016Article
- The effects of voluntary exercise on oocyte quality in a diet-induced obese murine model.Reproduction (Cambridge, England) · 2016Article
- Sex-dependent effects of developmental exposure to bisphenol A and ethinyl estradiol on metabolic parameters and voluntary physical activity.Journal of developmental origins of health and disease · 2015Article
- Maternal exercise before and during pregnancy does not impact offspring exercise or body composition in mice.Journal of negative results in biomedicine · 2015Article
- Quantitative genomics of voluntary exercise in mice: transcriptional analysis and mapping of expression QTL in muscle.Physiological genomics · 2014Article
- Fine-mapping QTLs in advanced intercross lines and other outbred populations.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Genetic determinants of voluntary exercise.Trends in genetics : TIG · 2013Review
- Exercise and diet affect quantitative trait loci for body weight and composition traits in an advanced intercross population of mice.Physiological genomics · 2012Article
- Functional genomic architecture of predisposition to voluntary exercise in mice: expression QTL in the brain.Genetics · 2012Article
- Identification of quantitative trait loci influencing skeletal architecture in mice: emergence of Cdh11 as a primary candidate gene regulating femoral morphology.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Sex-specific heterosis in line crosses of mice selectively bred for high locomotor activity.Behavior genetics · 2011Article
- Exercise, weight loss, and changes in body composition in mice: phenotypic relationships and genetic architecture.Physiological genomics · 2011Article
- Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Genetic architecture of voluntary exercise in an advanced intercross line of mice.Physiological genomics · 2010Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Despite the health-related benefits of exercise, many people do not engage in enough activity to realize the rewards, and little is known regarding the genetic or environmental components that account for this individual variation. We created and phenotyped a large G(4) advanced intercross line originating from reciprocal crosses between mice with genetic propensity for increased voluntary exercise (HR line) and the inbred strain C57BL/6J. G(4) females (compared to males) ran significantly more when provided access to a running wheel and were smaller with a greater percentage of body fat pre- and postwheel access. Change in body composition resulting from a 6-day exposure to wheels varied between the sexes with females generally regulating energy balance more precisely in the presence of exercise. We observed parent-of-origin effects on most voluntary wheel running and body composition traits, which accounted for 3-13% of the total phenotypic variance pooled across sexes. G(4) individuals descended from progenitor (F(0)) crosses of HRfemale symbol and C57BL/6Jmale symbol ran greater distances, spent more time running, ran at higher maximum speeds/day, and had lower percent body fat and higher percent lean mass than mice descended from reciprocal progenitor crosses (C57BL/6Jfemale symbol x HRmale symbol). For some traits, significant interactions between parent of origin and sex were observed. We discuss these results in the context of sex dependent activity and weight loss patterns, the contribution of parent-of-origin effects to predisposition for voluntary exercise, and the genetic (i.e., X-linked or mtDNA variations), epigenetic (i.e., genomic imprinting), and environmental (i.e., in utero environment or maternal care) phenomena potentially modulating these effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.