ArticleJournal of controlled release : official journal of the Controlled Release Society2010
Liposomal modular complexes for simultaneous targeted delivery of bioactive gases and therapeutics.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Optimized TELIP, an Echogenic Liposomal Nano-Carrier Loaded with Alteplase for Preclinical Studies.Pharmaceutics · 2026Article
- Sensitization of Hypoxic Tumors to Radiation Therapy Using Ultrasound-Sensitive Oxygen Microbubbles.International journal of radiation oncology, biology, physics · 2018Article
- Controlled release of nitric oxide from liposomes.ACS biomaterials science & engineering · 2017Article
- Nitric Oxide-Enhanced Molecular Imaging of Atheroma using Vascular Cellular Adhesion Molecule 1-Targeted Echogenic Immunoliposomes.Ultrasound in medicine & biology · 2015Article
- Development of an ultrasound sensitive oxygen carrier for oxygen delivery to hypoxic tissue.International journal of pharmaceutics · 2015Article
- Nitric oxide pretreatment enhances atheroma component highlighting in vivo with intercellular adhesion molecule-1-targeted echogenic liposomes.Ultrasound in medicine & biology · 2014Article
- Broadband attenuation measurements of phospholipid-shelled ultrasound contrast agents.Ultrasound in medicine & biology · 2014Article
- Nitric oxide improves molecular imaging of inflammatory atheroma using targeted echogenic immunoliposomes.Atherosclerosis · 2013Article
- Ultrasound-mediated drug delivery for cardiovascular disease.Expert opinion on drug delivery · 2013Review
- Passive imaging with pulsed ultrasound insonations.The Journal of the Acoustical Society of America · 2012Article
- Acoustic characterization of echogenic liposomes: frequency-dependent attenuation and backscatter.The Journal of the Acoustical Society of America · 2011Article
- Nanocarriers for nitric oxide delivery.Journal of drug delivery · 2011Article
- Ultrasound-enhanced delivery of targeted echogenic liposomes in a novel ex vivo mouse aorta model.Journal of controlled release : official journal of the Controlled Release Society · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Intrinsically echogenic liposomes (ELIP) can be adapted to encapsulate nitric oxide to facilitate ultrasound-enhanced delivery of therapeutic agents to atherosclerotic plaques. However, the NO loading of targeted ELIP caused a 93% decrease of antibody (Ab) immunoreactivity. The following hypothesis was tested: biotin/avidin-mediated coupling of NO-ELIP and Ab-conjugated ELIP will enable co-delivery of bioactive gases and ELIP that can encapsulate other agents without loss of targeting efficiency. Complex formation was initiated by addition of excess streptavidin to equal proportions of biotinylated Ab-ELIP and NO-ELIP. Fluorescence deconvolution microscopy, Coulter Multisizer 3 analysis and flow cytometry demonstrated that the ELIP coupling procedure formed mixed aggregates of >or=10 liposomes within 1 min. Intravascular ultrasound imaging and ELISA showed that echogenicity and targeting efficiency were completely and 69-99% retained, respectively. When complexed to NO-ELIP, ELIP bifunctionally targeted to both CD34 and ICAM-1 (BF-ELIP) increased human mononuclear cell migration through human coronary artery endothelial cell monolayers in transwell plates 4-fold relative to a nonspecific IgG-ELIP control and 2-fold relative to BF-ELIP alone. It was concluded that this novel multi-functional conjugation methodology provides a platform technology for site-specific co-delivery of bioactive gases and other agents.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.