ArticleInfluenza and other respiratory viruses2009
Genomic events underlying the changes in adamantane resistance among influenza A(H3N2) viruses during 2006-2008.
Article in Influenza and other respiratory viruses, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
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- Impact of a poorly performing point-of-care test during the 2017-2018 influenza season.The Journal of infection · 2019Article
- Synthesis of d-(+)-camphor-basedMedChemComm · 2018Article
- Resistance to Mutant Group 2 Influenza Virus Neuraminidases of an Oseltamivir-Zanamivir Hybrid Inhibitor.Journal of virology · 2016Article
- Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Efficacy of influenza vaccination and tamiflu® treatment--comparative studies with Eurasian Swine influenza viruses in pigs.PloS one · 2013Article
- Therapeutics against influenza.Current topics in microbiology and immunology · 2013Review
- Outbreak of H3N2 influenza at a US military base in Djibouti during the H1N1 pandemic of 2009.PloS one · 2013Article
- Structural basis for proton conduction and inhibition by the influenza M2 protein.Protein science : a publication of the Protein Society · 2012Review
- Cluster of oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infections on a hospital ward among immunocompromised patients--North Carolina, 2009.The Journal of infectious diseases · 2011Article
- Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus.Current opinion in structural biology · 2011Review
- Article
- Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel.Biochemistry · 2010Article
- Article
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10 authors.
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Abstract
backgroundAdamantanes resistance in H3N2 viruses has been increasing since 2000, and in 2005-2006 reached nearly 100% in most countries, with the circulation of the N-lineage. In 2006-2007, however, a significant decrease in resistance was observed in many regions.
objectivesTo explore potential links between adamantane resistance and the A(H3N2) viruses that circulated between 2006 and 2008.
methodsA total of 1451 Influenza A (H3N2) viruses collected globally in 2001-2008 were screened for the presence of adamantane resistance markers. A subset of 100 viruses representing the broad genetic and geographic spectrum of these viruses was selected for complete genome sequencing and phylogenetic analyses.
resultsFull genome sequence analysis of 2006-2007 viruses revealed co-circulation of four distinct genotypes, designated A-D. Phylogenetic analyses demonstrated reassortment between viruses from the N-lineage and other viruses that had circulated in prior seasons, including those bearing an adamantane sensitive marker. Genotype D viruses became dominant in late 2006-2007 and continued to be the main H3N2 genotype in 2007-2008. Viruses of this genotype retained all N-lineage genome segments except PB2 and NP, which were acquired through reassortment.
conclusionsThe decrease in adamantane resistance at that time was due to transient co-circulation of genotypes that emerged through reassortment. Our findings emphasize the importance of complete genome sequencing in understanding the complex nature of the relationship between influenza virus evolution and antiviral resistance. The recent emergence of the pandemic multi-reassortant H1N1 virus underscores the importance of whole genome sequence monitoring for rapid detection of such unusual and novel strains.
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