ArticleMolecular and cellular biology1991
Colony-stimulating factor 1 expression is down-regulated during the adipocyte differentiation of H-1/A marrow stromal cells and induced by cachectin/tumor necrosis factor.
Article in Molecular and cellular biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 45 citations in OpenAlex.
- Exogenous Nkx2.5- or GATA-4-transfected rabbit bone marrow mesenchymal stem cells and myocardial cell co-culture on the treatment of myocardial infarction in rabbits.Molecular medicine reports · 2015Article
- CCN3 and bone marrow cells.Journal of cell communication and signaling · 2009Article
- Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes.Nucleic acids research · 2006Article
- Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins.The Journal of clinical investigation · 2002Article
- EAT/mcl-1, a member of the bcl-2 related genes, confers resistance to apoptosis induced by cis-diammine dichloroplatinum (II) via a p53-independent pathway.Japanese journal of cancer research : Gann · 1998Article
- Adipocyte macrophage colony-stimulating factor is a mediator of adipose tissue growth.The Journal of clinical investigation · 1998Article
- Neurogenic potential of Ewing's sarcoma cells.Virchows Archiv : an international journal of pathology · 1997Article
- Cytokines, hematopoiesis, osteoclastogenesis, and estrogens.Calcified tissue international · 1992Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We isolated clonal sublines of the established mouse marrow stromal cell line, H-1. These clonal sublines underwent differentiation into adipocytes in various degrees. One subline, H-1/A, underwent adipocyte differentiation after confluence, while another subline, H-1/D, did not differentiate. In H-1/A cells, the 4.5- and 2.5-kb major mRNA species of colony-stimulating factor 1 (CSF-1) were expressed before differentiation and were down-regulated at a posttranscriptional level during the differentiation of H-1/A cells. The down-regulation of the CSF-1 gene was not a result of arrested cellular growth, because no down-regulation was detected in the nondifferentiating sister line, H-1/D. This down-regulation appeared to be an early event in differentiation. Cachectin/tumor necrosis factor transiently induced the expression of CSF-1 and inhibited the differentiation of H-1/A cells into adipocytes. This induced expression of CSF-1 was due to an increased rate of transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.