ArticleRapid communications in mass spectrometry : RCM2009
Changes in the natural abundance of 13CO2/12CO2 in breath due to lipopolysacchride-induced acute phase response.
Article in Rapid communications in mass spectrometry : RCM, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- The Breath Carbon Isotope Ratio Reflects Short-term Added-Sugar Intake in a Dose-Response, Crossover Feeding Study of 12 Healthy Adults.The Journal of nutrition · 2021Trial
- Article
- Seven unconfirmed ideas to improve future ICU practice.Critical care (London, England) · 2017Review
- Stable Isotope Ratios as Biomarkers of Diet for Health Research.Annual review of nutrition · 2015Review
- Breath carbon stable isotope ratios identify changes in energy balance and substrate utilization in humans.International journal of obesity (2005) · 2014Article
- Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome.Current Metabolomics · 2014Article
- NMR-based metabolomics and breath studies show lipid and protein catabolism during low dose chronic T(1)AM treatment.Obesity (Silver Spring, Md.) · 2013Article
- Novel diagnostics of metabolic dysfunction detected in breath and plasma by selective isotope-assisted labeling.Metabolism: clinical and experimental · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The natural abundance of carbon-13 in blood proteins increases during the cachectic state and may be a biomarker for disease status. We hypothesized a corresponding drop in the relative abundance of 13C in breath CO2. Using the lipopolysacchride (LPS)-induced endotoxemia model of the acute cachectic state, we demonstrated that the acute phase response causes shifts in the stable isotopes of carbon in exhaled CO2 (13CO2/12CO2 delta value) shortly after administration of LPS while glucocorticoid treatment does not. Mice were injected with LPS and stable isotopes of blood amino acids and carbon in exhaled CO2 were monitored. An increase in the relative isotopic mass of serum alanine, proline and threonine was observed at 3 h after LPS injection. Breath delta values began dropping immediately after administration of LPS, and were 4-5 delta values lower than those of the control animals by 2.5 h after injection. A corresponding drop in delta value was not observed with dexamethasone treatment. Thus protein synthesis during the acute phase response probably caused the fractionation of stable isotopes observed in the plasma amino acids and in exhaled breath 13CO2 delta values. The exhaled breath 13CO2 delta value may be a valuable real-time biomarker of cachexia associated with an acute phase response due to endotoxemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.