Evidence map›Paper›PMID 19902366›Full record

ArticleCancer causes & control : CCC2010

Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study.

Ilir Agalliu, Erika M Kwon, Claudia A Salinas, Joseph S Koopmeiners, Elaine A Ostrander, Janet L Stanford

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 26 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 26 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 26 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
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  3. hOGG1 rs1052133 Polymorphism and Prostate Cancer Risk: A Chinese Case-Control Study and Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2022
    Pooled it
  4. The Role of OPathology oncology research : POR · 2020
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  5. The potential role ofBioscience reports · 2018
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  13. Association between the XRCC1 Arg194Trp polymorphism and risk of cancer: evidence from 201 case-control studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
    Pooled it
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  15. Association between APE1 T1349G polymorphism and prostate cancer risk: evidence from a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
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  17. Association between X-ray repair cross-complementing group 1 Arg194Trp polymorphism and prostate cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
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  20. The polymorphisms in the MGMT gene and the risk of cancer: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ilir AgalliuDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA. ilir.agalliu@einstein.yu.edu
Erika M Kwon
Claudia A Salinas
Joseph S Koopmeiners
Elaine A Ostrander
Janet L Stanford
Fred Hutch Cancer Center · USNational Human Genome Research Institute · USAlbert Einstein College of Medicine · US

Funding

Finding Genes for Human Prostate CancerZIAHG200325 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI OSTRANDER, ELAINE · 2009 to 2021
$17.7M
Predoctoral Training Program in Human GeneticsT32GM007814 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 1985 to 2021
$10.6M
NSAIDS and Other Medications in Prostate Cancer EtiologyR01CA092579 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STANFORD, JANET L · 2001 to 2005
$3.2M
SURVEILLANCE EPIDEMIOLOGY AND END RESULTSN01CN005230 · CN · FRED HUTCHINSON CANCER RESEARCH CENTER · PI THOMAS, DAVID B · 1990 to 1996
–
PROSTATE CANCER IN RELATION TO VASECTOMYR01CA056678 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STANFORD, JANET L · 1993 to 1997
–
Intramural NIH HHSNCI NIH HHS N01 CN005230NCI NIH HHS R01 CA056678NCI NIH HHS R01 CA092579NCI NIH HHS R01-CA092579NCI NIH HHS R01-CA56678NIGMS NIH HHS T32 GM007814
6 · The paper itself

Abstract

objectiveDNA repair pathways are crucial to prevent accumulation of DNA damage and maintain genomic stability. Alterations of this pathway have been reported in many cancers. An increase in oxidative DNA damage or decrease in DNA repair capacity with aging or due to germline genetic variation may affect prostate cancer risk.

methodsPooled data from two population-based studies (1,457 cases and 1,351 controls) were analyzed to examine associations between 28 single-nucleotide polymorphisms (SNPs) in nine DNA repair genes (APEX1, BRCA2, ERCC2, ERCC4, MGMT, MUTYH, OGG1, XPC, and XRCC1) and prostate cancer risk. We also explored whether associations varied by smoking, by family history or clinical features of prostate cancer.

resultsThere were no associations between these SNPs and overall risk of prostate cancer. Risks by genotype also did not vary by smoking or by family history of prostate cancer. Although two SNPs in BRCA2 (rs144848, rs1801406) and two SNPs in ERCC2 (rs1799793, rs13181) showed stronger associations with high Gleason score or advanced-stage tumors when comparing homozygous men carrying the minor versus major allele, results were not statistically significantly different between clinically aggressive and non-aggressive tumors.

conclusionOverall, this study found no associations between prostate cancer and the SNPs in DNA repair genes. Given the complexity of this pathway and its crucial role in maintenance of genomic stability, a pathway-based analysis of all 150 genes in DNA repair pathways, as well as exploration of gene-environment interactions may be warranted.

Indexed as

Polymorphism, Single NucleotideAdultAgedBlack or African AmericanBRCA2 ProteinChi-Square DistributionDNA RepairGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansLinkage DisequilibriumMaleMiddle AgedPopulation SurveillanceBRCA2 ProteinERCC2 protein, humanXeroderma Pigmentosum Group D Protein

Identifiers

PMID19902366
PMCPMC2811225
OpenAlexW2051113868

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.