ArticleJournal of the Association for Research in Otolaryngology : JARO2010
Effects of hearing preservation on psychophysical responses to cochlear implant stimulation.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06375278 (Device to Deliver Intra-Operative Therapeutic Hypothermia for Hearing Preservation in Cochlear Implantation), which is not on this map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Device to Deliver Intra-Operative Therapeutic Hypothermia for Hearing Preservation in Cochlear Implantation
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cochlear implant re-mapping informed by measures of viability of the electrode-neural interface: a systematic review with meta-analysis.Scientific reports · 2025Pooled it
- Implications of phase difference and amplitude ratio from intracochlear and extracochlear electrocochleography in normal-hearing guinea pigs.Frontiers in neuroscience · 2026Article
- Exploring the relationship between electrophysiological measures of the electrically evoked auditory brainstem response and speech perception outcomes post-cochlear implantation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Electrically evoked compound action potential polarity sensitivity, refractory-recovery, and behavioral multi-pulse integration as potential indices of neural health in cochlear-implant recipients.Hearing research · 2023Article
- Cochlear Health and Cochlear-implant Function.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Estimating health of the implanted cochlea using psychophysical strength-duration functions and electrode configuration.Hearing research · 2022Article
- Development of a chronically-implanted mouse model for studies of cochlear health and implant function.Hearing research · 2021Article
- Recovery from forward masking in cochlear implant listeners: Effects of age and the electrode-neuron interface.The Journal of the Acoustical Society of America · 2021Article
- Evaluating and Comparing Behavioural and Electrophysiological Estimates of Neural Health in Cochlear Implant Users.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- The Neural Processing of Vocal Emotion After Hearing Reconstruction in Prelingual Deaf Children: A Functional Near-Infrared Spectroscopy Brain Imaging Study.Frontiers in neuroscience · 2021Article
- eABR THR Estimation Using High-Rate Multi-Pulse Stimulation in Cochlear Implant Users.Frontiers in neuroscience · 2021Article
- How electrically evoked compound action potentials in chronically implanted guinea pigs relate to auditory nerve health and electrode impedance.The Journal of the Acoustical Society of America · 2020Article
- Cochlear implants and other inner ear prostheses: today and tomorrow.Current opinion in physiology · 2020Article
- Relationships between Intrascalar Tissue, Neuron Survival, and Cochlear Implant Function.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
- Effects of Electrode Location on Estimates of Neural Health in Humans with Cochlear Implants.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
- Investigation of Electrically Evoked Auditory Brainstem Responses to Multi-Pulse Stimulation of High Frequency in Cochlear Implant Users.Frontiers in neuroscience · 2020Article
- The Influence of Cochlear Implant-Based Electric Stimulation on the Electrophysiological Characteristics of Cultured Spiral Ganglion Neurons.Neural plasticity · 2020Article
- Changes over time in the electrically evoked compound action potential (ECAP) interphase gap (IPG) effect following cochlear implantation in Guinea pigs.Hearing research · 2019Article
- Use of the guinea pig in studies on the development and prevention of acquired sensorineural hearing loss, with an emphasis on noise.The Journal of the Acoustical Society of America · 2019Review
- Anatomical Correlates and Surgical Considerations for Localized Therapeutic Hypothermia Application in Cochlear Implantation Surgery.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Previous studies have shown that residual acoustic hearing supplements cochlear implant function to improve speech recognition in noise as well as perception of music. The current study had two primary objectives. First, we sought to determine how cochlear implantation and electrical stimulation over a time period of 14 to 21 months influence cochlear structures such as hair cells and spiral ganglion neurons. Second, we sought to investigate whether the structures that provide acoustic hearing also affect the perception of electrical stimulation. We compared psychophysical responses to cochlear implant stimulation in two groups of adult guinea pigs. Group I (11 animals) received a cochlear implant in a previously untreated ear, while group II (ten animals) received a cochlear implant in an ear that had been previously infused with neomycin to destroy hearing. Psychophysical thresholds were measured in response to pulse-train and sinusoidal stimuli. Histological analysis of all group I animals and a subset of group II animals was performed. Nine of the 11 group I animals showed survival of the organ of Corti and spiral ganglion neurons adjacent to the electrode array. All group I animals showed survival of these elements in regions apical to the electrode array. Group II animals that were examined histologically showed complete loss of the organ of Corti in regions adjacent and apical to the electrode array and severe spiral ganglion neuron loss, consistent with previous reports for neomycin-treated ears. Behaviorally, group II animals had significantly lower thresholds than group I animals in response to 100 Hz sinusoidal stimuli. However, group I animals had significantly lower thresholds than group II animals in response to pulse-train stimuli (0.02 ms/phase; 156 to 5,000 pps). Additionally, the two groups showed distinct threshold versus pulse rate functions. We hypothesize that the differences in detection thresholds between groups are caused by the electrical activation of the hair cells in group I animals and/or differences between groups in the condition of the spiral ganglion neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.