Trial reportPediatric nephrology (Berlin, Germany)2010
Ibuprofen in very preterm infants impairs renal function for the first month of life.
Trial report in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review.Frontiers in pediatrics · 2020Pooled it
- PDA in Prematurity: Rethinking a Decades-Old Debate in 2026.Biomedicines · 2026Review
- Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-Analysis.Children (Basel, Switzerland) · 2025Review
- Sex Differences in Patent Ductus Arteriosus Incidence and Response to Pharmacological Treatment in Preterm Infants: A Systematic Review, Meta-Analysis and Meta-Regression.Journal of personalized medicine · 2022Review
- Efficacy and Safety of Oral Paracetamol vs. Oral Ibuprofen in the Treatment of Symptomatic Patent Ductus Arteriosus in Premature Infants.Paediatric drugs · 2019Article
- Acute kidney injury in an extremely low birth weight infant with nephrolithiasis: a case report.Acta medica Lituanic · 2018Article
- The spectrum of onset of acute kidney injury in premature infants less than 30 weeks gestation.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Lung function in very preterm infants with patent ductus arteriosus under conservative management: an observational study.BMC pediatrics · 2015Observational
- Cyclooxygenase (COX) Inhibitors and the Newborn Kidney.Pharmaceuticals (Basel, Switzerland) · 2012Article
- Increased urinary podocytes following indomethacin suggests drug-induced glomerular injury.Pediatric nephrology (Berlin, Germany) · 2012Article
- Evidence-based use of indomethacin and ibuprofen in the neonatal intensive care unit.Clinics in perinatology · 2012Review
- Postnatal trends in creatinemia and its covariates in extremely low birth weight (ELBW) neonates.Pediatric nephrology (Berlin, Germany) · 2011Article
- Comparison of renal effects of ibuprofen versus indomethacin during treatment of patent ductus arteriosus in contiguous historical cohorts.BMC clinical pharmacology · 2011Article
- Should we definitively abandon prophylaxis for patent ductus arteriosus in preterm new-borns?Clinics (Sao Paulo, Brazil) · 2011Review
- The renal adverse effects of ibuprofen are not mediated by AQP2 water channels.Pediatric nephrology (Berlin, Germany) · 2010Article
- Transplantation: Nephrectomy of a failed allograft decreases mortality.Nature reviews. Nephrology · 2010Article
- Renal Side Effects of Non-Steroidal Anti-Inflammatory Drugs in Neonates.Pharmaceuticals (Basel, Switzerland) · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We carried out a study aiming to determine the renal effect of ibuprofen treatment for patent ductus arteriosus (PDA) in very preterm infants during the first month of life. Infants aged 27-31 weeks gestation were enrolled from October 2004 to August 2006. They were assigned to two different groups according to ibuprofen exposure during care of their PDA status assessed by echocardiography. Infants of both groups were matched based on gestational age, Clinical Risk Index for Babies score, birth weight and inclusion center. Renal function was evaluated at baseline and weekly for 1 month. One hundred and forty-eight infants were enrolled. Glomerular filtration rate (GFR) was significantly decreased in the ibuprofen group after treatment withdrawal (GFR on day 7, ibuprofen versus no ibuprofen: 12.8 +/- 6.2 vs. 18.1 +/- 12.1 ml/min/1.73 m(2); P < 0.001). Adjusted analysis proved this decrease to be sustained during the first month of life. Tubular function was also impaired during the first month in ibuprofen-treated infants. Ibuprofen administered for PDA is associated with a decreased GFR during the first month of life. Renal function of infants receiving ibuprofen should be carefully monitored and drugs that are eliminated by glomerular filtration handled cautiously during this period.
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