Evidence map›Paper›PMID 19902247›Full record

ArticleMedical microbiology and immunology2010

Cellular immune response to Mycobacterium tuberculosis-specific antigen culture filtrate protein-10 in south India.

Madhan Kumar, Jagadish C Sundaramurthi, Narinder K Mehra, Gurvinder Kaur, Alamelu Raja

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In one paragraph

Article in Medical microbiology and immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Madhan KumarDepartment of Immunology, Tuberculosis Research Centre (ICMR), Chennai, India.
Jagadish C Sundaramurthi
Narinder K Mehra
Gurvinder Kaur
Alamelu Raja
National Institute of Research in Tuberculosis · INAll India Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Mycobacterium tuberculosis (M. tuberculosis)-specific culture filtrate protein-10 (CFP-10) is highly recognized by M. tuberculosis infected subjects. In the present study, the proliferative response and IFN-gamma secretion was found for C-terminal peptides of the protein (Cfp6(51-70), Cfp7(61-80), Cfp8(71-90), and Cfp9(81-100)). The alleles HLA DRB1 *04 and HLA DRB1 *10 recognized the C-terminal peptides Cfp7, Cfp8, and Cfp9 in HHC. Cfp6 was predominantly recognized by the alleles HLA DRB1 *03 and HLA DRB1 *15 by PTB. The minimal nonameric epitopes from the C-terminal region were CFP-10(56-64) and CFP-10(76-84). These two peptides deserve attention for inclusion in a vaccine against tuberculosis in this region.

Indexed as

AdultAntigens, BacterialBacterial ProteinsCell ProliferationCells, CulturedEpitope MappingEpitopes, T-LymphocyteFemaleHLA-DR AntigensHLA-DRB1 ChainsHumansIndiaInterferon-gammaLeukocytes, MononuclearMaleMiddle AgedAntigens, BacterialBacterial ProteinsCFP-10 protein, Mycobacterium tuberculosisCFP 6 protein, Mycobacterium tuberculosisEpitopes, T-LymphocyteHLA-DR AntigensHLA-DRB1 ChainsInterferon-gamma

Identifiers

PMID19902247
OpenAlexW2050777570

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.