ArticleHistochemistry and cell biology2010
Tissue reaction to three different types of tissue glues in an experimental aorta dissection model: a quantitative approach.
Article in Histochemistry and cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Real-World Performance of the Veriset Hemostatic Patch: A Multicenter Study of Adjunctive Hemostasis.Medical devices (Auckland, N.Z.) · 2026Article
- Characterization of a Novel POx-Based Adhesive Powder for Obliterating Dead Spaces After Surgery.Bioengineering (Basel, Switzerland) · 2025Article
- Unlocking the secrets of aortic pseudoaneurysms - exploring tensile testing of prostheses, anastomoses, and native vessels in the thoracic aorta: A clinical-engineering correlation.Journal of applied biomedicine · 2025Article
- Aortic lumen repair with glue-felt technique before proximal anastomosis in acute type a aortic dissection surgery.Journal of cardiothoracic surgery · 2025Article
- Photo-Cross-Linkable, Injectable, and Highly Adhesive GelMA-Glycol Chitosan Hydrogels for Cartilage Repair.Advanced healthcare materials · 2023Article
- Article
- Hyperbaric oxygen enhances collagen III formation in wound of ZDF rat.Physiological research · 2021Article
- Bioadhesives for musculoskeletal tissue regeneration.Acta biomaterialia · 2020Review
- Neomedia Repair of the Valsalva Sinus in the Treatment of Acute Type-A Aortic Dissection: Long-term Effectiveness and a Case of Pathology.Annals of vascular diseases · 2020Article
- Tissue reactions to polyethylene glycol and glutaraldehyde-based surgical sealants in a rabbit aorta model.Journal of biomaterials applications · 2020Article
- Aortic α-smooth muscle actin expressions in aortic disorders and coronary artery disease: An immunohistochemical study.Anatolian journal of cardiology · 2018Article
- Vascular histopathologic reaction to pulmonary artery banding in an in vivo growing porcine model.Pediatric cardiology · 2013Article
- A case of ascending aortic pseudoaneurysm in a patient with aortic replacement.General thoracic and cardiovascular surgery · 2012Article
- A highly elastic and adhesive gelatin tissue sealant for gastrointestinal surgery and colon anastomosis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012Article
- Initial stability of two different adhesives compared to suture repair for acute Achilles tendon rupture--a biomechanical evaluation.International orthopaedics · 2012Article
- BioGlue in 2011: what is its role in cardiac surgery?The journal of extra-corporeal technology · 2012Article
- Histochemistry and cell biology: the annual review 2010.Histochemistry and cell biology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue glues are used during surgical treatment of acute aorta dissection although some glues release toxic products and thus alter the histological structure of the vessel wall. The aim of our study was to use a porcine experimental model of infrarenal aorta dissection to compare histological changes of the vessel wall 1, 6 and 12 months after application of BioGlue, Gelatin-resorcin-formaldehyde (GRF) glue and Tissucol. For quantification, stereological methods were used. All types of glue caused stenosis, GRF most and Tissucol least severely. With increasing postoperative survival time, stenosis was again reduced. Elastine length density decreased with increasing survival time in Control as well as in all Experimental groups. The immunohistochemical phenotype of vascular smooth muscle cells was similar in Tissucol and Control samples. In GRF samples, actin, desmin and vimentin expression changed most severely. Similarly, number and distribution of vasa vasorum in the aortic wall was altered most severely in GRF samples. They tended to return to normal with increasing postoperative survival time, but at a slow rate in the GRF samples. It can be concluded that GRF causes the most severe histopathological changes within the treated aorta, which could be a reason for late failures of dissection surgery. However, glue handling and adhesive properties have to be taken into account, too, when certain glue is chosen for surgical intervention. Increased inflammation and vascularisation might even stabilise the aortic wall. Long-term experimental studies would be helpful to assess healing processes after initial disorganisation of the aortic wall structure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.