ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2010
Clinical applications of biomarkers in pediatric traumatic brain injury.
Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Effect of anti-seizure drugs on serum S100B in patients with focal seizure: a randomized controlled trial.Journal of neurology · 2018Trial
- Effects of ulinastatin on early postoperative cognitive function after one-lung ventilation surgery in elderly patients receiving neoadjuvant chemotherapy.Metabolic brain disease · 2017Trial
- Determination of Serum Lost Goodwill Target Proteome in Patients with Severe Traumatic Brain Injury.BioMed research international · 2015Trial
- Research progress on biomarkers of traumatic brain injury.Animal models and experimental medicine · 2026Review
- Study of ubiquitin C-terminal hydrolase-L1, glial fibrillary acidic protein, and interleukin-6 levels in an experimental head trauma model in rabbits.Clinical and experimental emergency medicine · 2025Article
- Comparative Assessment of Quality of Life and Serum S100B in Epilepsy Treated with Newer and Conventional Drugs: A Pharmacoeconomic Perspective.Journal of epilepsy research · 2025Article
- Metabolomic in severe traumatic brain injury: exploring primary, secondary injuries, diagnosis, and severity.Critical care (London, England) · 2025Article
- Serum tau protein and myelin basic protein in pediatric patients with congenital heart defects undergoing cardiac surgery: preliminary assessment as novel neuromarkers of brain injury.Irish journal of medical science · 2024Article
- Biomarkers in Moderate to Severe Pediatric Traumatic Brain Injury: A Review of the Literature.Pediatric neurology · 2022Review
- Serum biomarkers in severe paediatric traumatic brain injury-a narrative review.Translational pediatrics · 2021Review
- Blood Biomarkers for Traumatic Brain Injury: A Quantitative Assessment of Diagnostic and Prognostic Accuracy.Frontiers in neurology · 2019Review
- Unbiased Proteomic Approach Identifies Unique and Coincidental Plasma Biomarkers in Repetitive mTBI and AD Pathogenesis.Frontiers in aging neuroscience · 2018Article
- Serum S100B Levels Can Predict Computed Tomography Findings in Paediatric Patients with Mild Head Injury.BioMed research international · 2018Article
- Neuroinflammation, myelin and behavior: Temporal patterns following mild traumatic brain injury in mice.PloS one · 2017Article
- Phage display for identification of serum biomarkers of traumatic brain injury.Journal of neuroscience methods · 2016Article
- Scalp Haematoma in Cerebral Palsy Case due to Unknown Cause - A Rare Case Report.Journal of clinical and diagnostic research : JCDR · 2016Article
- Current status of fluid biomarkers in mild traumatic brain injury.Experimental neurology · 2016Review
- Chapter 6 state of the science of pediatric traumatic brain injury: biomarkers and gene association studies.Annual review of nursing research · 2015Review
- Hypermethylation of the enolase gene (ENO2) in autism.European journal of pediatrics · 2014Article
- Perspectives on molecular biomarkers of oxidative stress and antioxidant strategies in traumatic brain injury.BioMed research international · 2014Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe diagnosis, treatment, and prediction of outcome in pediatric traumatic brain injury (TBI) present significant challenges to the treating clinician. Clinical and radiological tools for assessing injury severity and predicting outcome, in particular, lack sensitivity and specificity. In patients with mild TBI, often there is uncertainty about which patients should undergo radiological imaging and who is at risk for long term neurological sequelae. In severe TBI, often there is uncertainty about which patients will experience secondary insults and what the outcome for individual patients will be. In several other clinical specialties, biomarkers are used to diagnose disease, direct treatment, and prognosticate. However, an ideal biomarker for brain injury has not been found.
methodsIn this review, we examine the various factors that must be taken into account in the search for a reliable biomarker in brain injury. We review the important studies that have investigated common biomarkers of structural brain injury, in particular S100B, neuron-specific enolase, myelin basic protein, and glial fibrillary acid protein. DISCUSSION: The potential uses and limitations of these biomarkers in the context of TBI are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.